Chemical and pharmacological characterization of hypolipidemic compound from Cajanus Cajan

Authors

  • Md. Anwar Habib Department of Pharmacology, Rajshahi Medical College, Rajshahi 6000
  • Abu Syed Md Anisuzzaman Department of Pharmacy, University of Rajshahi, Rajshahi 6205
  • Md. Rofiqul Islam Khan Department of Pharmacy, University of Rajshahi, Rajshahi 6205
  • Md. Abdul Gafur Department of Pharmacy, University of Rajshahi, Rajshahi 6205

DOI:

https://doi.org/10.3329/bjp.v5i1.5158

Keywords:

Cajanus cajan, Chromatography, Diabetic mice, Hypolipidemic activity, Redgram, Streptozotocin

Abstract

The study was carried out to identify the compound responsible for hypolipidemic and hypoglycemic effects of Cajanus cajan (redgram). The methanol extract of redgram seeds were fractionated into petroleum ether, chloroform, and methanol.The methanol fraction significantly decreased fasting blood glucose, and lipid profiles (p<0.001) on streptozotocin-induced mice compared to control. The methanol fraction was then subjected to chromatographic analysis and a compound (CCA1) has been isolated. The structure of the compound is considered to be substituted cyclopentene with glucose by analysis its 1H and 13C-NMR data. Biological studies of the isolated compound possessed prominent hypolipidemic activity. Although a number of hypoglycemic compounds are reported, yet not any hypolipidemic compound from redgram.The compound CCA1 seems to be the first report on hypolipidemic activity from methanol extract of redgram.

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Author Biography

Md. Anwar Habib, Department of Pharmacology, Rajshahi Medical College, Rajshahi 6000

Professor

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Additional Files

Published

2010-05-30

How to Cite

Habib, M. A., A. S. M. Anisuzzaman, M. R. I. Khan, and M. A. Gafur. “Chemical and Pharmacological Characterization of Hypolipidemic Compound from Cajanus Cajan”. Bangladesh Journal of Pharmacology, vol. 5, no. 1, May 2010, pp. 34-38, doi:10.3329/bjp.v5i1.5158.

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Section

Research Articles