In vitro study of antiamoebic effect of methanol extract of mature seeds of Carica papaya on trophozoites of Entamoeba histolytica


  • Sujit Kumar Sarker Department of Pharmacology and Therapeutics, Dhaka Medical College, Dhaka 1000
  • Nilufar Begum Department of Pharmacology and Therapeutics, Shahabuddin Medical College, Dhaka 1212
  • Dinesh Mondal Parasitology Laboratory, ICDDR'B, Dhaka 1212
  • Md. Abdullah Siddique Parasitology Laboratory, ICDDR'B, Dhaka 1212
  • Mohammad A. Rashid Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka 1000



Amoebiasis, Entamoeba histolytica, Carica papaya


Antiamoebic activity of methanol extract of mature seeds of Carica papaya was tested in vitro on axenic culture of Entamoeba histolytica using metronidazole as a reference amoebicidal agent. The MIC of seed extract was >62.5 µg/mL as compared to <0.8 µg/mL for metronidazole. The present study suggests that the mature seeds of C.  papaya have antiamoebic effect but less pronounced than metronidazole.


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Author Biography

Sujit Kumar Sarker, Department of Pharmacology and Therapeutics, Dhaka Medical College, Dhaka 1000

Assistant Professor


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How to Cite

Sarker, S. K., N. Begum, D. Mondal, M. A. Siddique, and M. A. Rashid. “In Vitro Study of Antiamoebic Effect of Methanol Extract of Mature Seeds of Carica Papaya on Trophozoites of Entamoeba Histolytica”. Bangladesh Journal of Pharmacology, vol. 5, no. 1, June 2010, pp. 45-47, doi:10.3329/bjp.v5i1.5003.



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