In vitro study of antiamoebic effect of methanol extract of mature seeds of Carica papaya on trophozoites of Entamoeba histolytica

Authors

  • Sujit Kumar Sarker Department of Pharmacology and Therapeutics, Dhaka Medical College, Dhaka 1000
  • Nilufar Begum Department of Pharmacology and Therapeutics, Shahabuddin Medical College, Dhaka 1212
  • Dinesh Mondal Parasitology Laboratory, ICDDR'B, Dhaka 1212
  • Md. Abdullah Siddique Parasitology Laboratory, ICDDR'B, Dhaka 1212
  • Mohammad A. Rashid Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka 1000

DOI:

https://doi.org/10.3329/bjp.v5i1.5003

Keywords:

Amoebiasis, Entamoeba histolytica, Carica papaya

Abstract

Antiamoebic activity of methanol extract of mature seeds of Carica papaya was tested in vitro on axenic culture of Entamoeba histolytica using metronidazole as a reference amoebicidal agent. The MIC of seed extract was >62.5 µg/mL as compared to <0.8 µg/mL for metronidazole. The present study suggests that the mature seeds of C.  papaya have antiamoebic effect but less pronounced than metronidazole.

Downloads

Download data is not yet available.
Abstract
1169
Download
928 Read
193

Author Biography

Sujit Kumar Sarker, Department of Pharmacology and Therapeutics, Dhaka Medical College, Dhaka 1000

Assistant Professor

References

Andrews JM. Determination of minimum inhibitory concentrations. J Antimicrob Chemother. 2001; 48: 5-16.

Bansal D, Sehgal R, Chawla Y, Malla N, Mahajan RC. Multidrug resistance in amoebiasis patient. Indian J Med Res. 2006; 124: 189-94.

Calzada F, Yepez-mulia L, Aguilar A. In vitro susceptibility of Entamoeba histolytica and Giardia lamblia to plants used in Mexican traditional medicine for the treatment of gastrointestinal disorders. J Ethnopharmacol. 2006; 108: 367-70.

Clark CG, Diamond LS. Methods for cultivation of luminal parasitic protists of clinical importance. Clin Microbiol Rev. 2002; 15: 329-41.

Ghani A. Carica papaya (Linn). In: Ghani A, (ed). Medicinal plants of Bangladesh with chemical constituents. 2nd ed. Dhaka, Asiatic Society of Bangladesh, 2003, p149.

Krishna KL, Paridhavi M, Patel JA. Review on nutritional, medicinal and pharmacological properties of papaya (Carica papaya Linn.). Nat Prod Radian. 2008; 7: 364-73.

Lakshmi V, Saxena A, Mishra SK, Mishra M, Srivastava S, Ghoshal S. Antiamoebic activity of marine sponge Haliclona exigua (Krikpatrick). Bangladesh J Pharmacol. 2009; 4: 55-59.

Tona L, Kambu K, Ngimbi N, Cimanga K, Vlietinck AJ. Antiamoebic and phytochemical screening of some Congolese medicinal plants. J Ethnopharmacol. 1998; 61: 57-65.

Additional Files

Published

2010-06-27

How to Cite

Sarker, S. K., N. Begum, D. Mondal, M. A. Siddique, and M. A. Rashid. “In Vitro Study of Antiamoebic Effect of Methanol Extract of Mature Seeds of Carica Papaya on Trophozoites of Entamoeba Histolytica”. Bangladesh Journal of Pharmacology, vol. 5, no. 1, June 2010, pp. 45-47, doi:10.3329/bjp.v5i1.5003.

Issue

Section

Research Articles