Synthesis of isatin, 5-chloroisatin and their Δ<sup>2</sup>-1,3,4 oxadiazoline derivatives for comparative cytotoxicity study on brine shrimp
Isatin (3a), isatin 3-carbohydrazone (4a), 5-spiro (isatin) 2-(N-acetyl hydra-zino) 4-(N-acetyl)-?2-1,3,4 oxadiazoline (5a), and 5-spiro (isatin) 2-hydrazino-?2-1,3,4 oxadiazoline (6a) had been synthesized from the unsubstituted oximinoacetanilide (2a). 4-Chlorooximinoacetanilide (2b), 5-chloroisatin (3b), 5-chloroisatin 3-carbohydrazone (4b) and 5-spiro (5¢-chloroisatin) 2-(N-acetyl hydrazino) 4-N-acetyl ?2-1,3,4 oxadiazoline (5b) compounds had been synthesized from p-chloroaniline. The structures of the products had been characterized from the spectral analysis and comparative cytotoxicity study of them was studied.
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