Synthesis of isatin, 5-chloroisatin and their &Delta;<sup>2</sup>-1,3,4 oxadiazoline derivatives for comparative cytotoxicity study on brine shrimp

  • Md. Rabiul Islam Department of Chemistry, Jahangirnagar University, Savar, Dhaka 1342
  • Mohammad Mohsin Department of Chemistry, Jahangirnagar University, Savar, Dhaka 1342
Keywords: Chloroisatin, Cytotoxicity, Oxadiazoline


Isatin (3a), isatin 3-carbohydrazone (4a), 5-spiro (isatin) 2-(N-acetyl hydra-zino) 4-(N-acetyl)-?2-1,3,4 oxadiazoline (5a), and 5-spiro (isatin) 2-hydrazino-?2-1,3,4 oxadiazoline (6a) had been synthesized from the unsubstituted oximinoacetanilide (2a). 4-Chlorooximinoacetanilide (2b), 5-chloroisatin (3b), 5-chloroisatin 3-carbohydrazone (4b) and 5-spiro (5¢-chloroisatin) 2-(N-acetyl hydrazino) 4-N-acetyl ?2-1,3,4 oxadiazoline (5b) compounds had been synthesized from p-chloroaniline. The structures of the products had been characterized from the spectral analysis and comparative cytotoxicity study of them was studied.


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How to Cite
Islam, M., and M. Mohsin. “Synthesis of Isatin, 5-Chloroisatin and Their &Delta;<sup>2</Sup&gt;-1,3,4 Oxadiazoline Derivatives for Comparative Cytotoxicity Study on Brine Shrimp”. Bangladesh Journal of Pharmacology, Vol. 2, no. 1, 1, pp. 7-12, doi:10.3329/bjp.v2i1.494.
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