Effect of folic acid and tetrahydrofolate on tissue arsenic level in rat

Authors

  • Md. Faizur Rahman Department of Pharmacology, Faculty of Basic Sciences, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka 1000
  • Mir Misbahuddin Department of Pharmacology, Faculty of Basic Sciences, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka 1000

DOI:

https://doi.org/10.3329/bjp.v5i1.4909

Keywords:

Arsenic, Folic acid, Tetrahydrofolate

Abstract

Quest is still going on for a cheap, effective, and easily available remedy for chronic arsenic toxicity. This study was designed to investigate the effects of folic acid and tetrahydrofolate in lowering the arsenic burden in tissues. Rats received arsenic at 700 µg/day by gavage for 28 days except the control group. Arsenic accumulation was significantly lowered (p<0.05), in liver, kidney, heart, lung and skin in both the folic acid and tetrahydrofolate-treated groups compared to arsenic only treated group. The oxidative stress induced by arsenic treatment was reduced as evident by the reduction in rise of malondialdehyde level in both groups. But folic acid was found to be more efficacious compared to tetrahydrofolate. 

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Additional Files

Published

2010-05-22

How to Cite

Rahman, M. F., and M. Misbahuddin. “Effect of Folic Acid and Tetrahydrofolate on Tissue Arsenic Level in Rat”. Bangladesh Journal of Pharmacology, vol. 5, no. 1, May 2010, pp. 25-29, doi:10.3329/bjp.v5i1.4909.

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Section

Research Articles