Condensation reaction of benzil with resorcinol and the establishment of the spectral data as well as cytotoxicity study

Authors

  • A. Kashem Liton Department of Chemistry, Jahangirnagar University, Savar, Dhaka 1342
  • M. Rabiul Islam Department of Chemistry, Jahangirnagar University, Savar, Dhaka 1342

DOI:

https://doi.org/10.3329/bjp.v1i2.489

Keywords:

Benzil, Cytotoxic, Resorcinol

Abstract

Condensation of benzil, 1 with resorcinol in the presence of potassium carbonate at 110-120°C gave the mixture of the compounds. Using various kinds of separation technique only five types of the polymeric products, a1, a2, a3, a4 and a5 were isolated. The compounds a1, a4 showed high cytotoxic activity and the compounds a2, a3 and a5 showed relatively low cytotoxic activity against the brine shrimp lethality bioassay.

 

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References

Anderson JE, Goetz CM, McLaughlin JL, Suffness M. Phytochemical analysis. 4th ed. Oxford University Press, 1991, pp 107-10.

Islam MR, Khayer K, Mahmud MI. Reaction of isatin with 2-aminothiophenol leading to spiroheterocyclic having anti-cancer activity. Jahangirnagar Univ J Sci. 2001a; 24: 17-22.

Islam R, Khayer K, Abedin MJ, Islam MR. Synthesis of (5-spiro(5´-methylisatin)-4-acetyl-2-(acetylamino)?¬¬2-,3,4-thiadiazoline and 5-spiro (5´-methylisatin)-4-acetyl-2-(5´-methylisatin-3´-hydrazineo)-?¬¬2-1,3,4-thiadiazoline, Indian J Chem. 2001b; 40B: 240-42.

Lingcon MH, Islam R, Khayer K, Islam MR. Cyclization of substituted indole-2-one-3-thiosemicarbazones to noble heterocyclic systems. J Bangladesh Chem. Soc. 2001; 14: 127-32.

von Liebig H. Condensation reaction of benzil with resorcinol. J Prac Chem. 1905; 74: 345-59.

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How to Cite

Liton, A. K., and M. R. Islam. “Condensation Reaction of Benzil With Resorcinol and the Establishment of the Spectral Data As Well As Cytotoxicity Study”. Bangladesh Journal of Pharmacology, vol. 1, no. 2, Dec. 2006, pp. 58-63, doi:10.3329/bjp.v1i2.489.

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Section

Research Articles