Synthesis of some pyrazolone derivatives from ciprofloxacin and study of their cytotoxicity


  • Hari Pado Devnath Department of Chemistry, Jahangirnagar University, Savar, Dhaka 1342
  • Md. Rabiul Islam Department of Chemistry, Jahangirnagar University, Savar, Dhaka 1342



Ciprofloxacin, Cytotoxicity, Pyrazolone


Three pyrazolone derivativeswith pyrazole ring extensionwere synthesized from ciprofloxacin by treating the parent compound with hydrazine derivatives. All the products have been characterized by IR and 1H-NMR spectral analysis. These derivatives showed potential cytotoxicity against brine shrimp nauplii than the ciprofloxacin.


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Author Biographies

Hari Pado Devnath, Department of Chemistry, Jahangirnagar University, Savar, Dhaka 1342


Md. Rabiul Islam, Department of Chemistry, Jahangirnagar University, Savar, Dhaka 1342



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How to Cite

Devnath, H. P., and M. R. Islam. “Synthesis of Some Pyrazolone Derivatives from Ciprofloxacin and Study of Their Cytotoxicity”. Bangladesh Journal of Pharmacology, vol. 5, no. 1, May 2010, pp. 30-33, doi:10.3329/bjp.v5i1.4693.



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