Synthesis of some pyrazolone derivatives from ciprofloxacin and study of their cytotoxicity

Authors

  • Hari Pado Devnath Department of Chemistry, Jahangirnagar University, Savar, Dhaka 1342
  • Md. Rabiul Islam Department of Chemistry, Jahangirnagar University, Savar, Dhaka 1342

DOI:

https://doi.org/10.3329/bjp.v5i1.4693

Keywords:

Ciprofloxacin, Cytotoxicity, Pyrazolone

Abstract

Three pyrazolone derivativeswith pyrazole ring extensionwere synthesized from ciprofloxacin by treating the parent compound with hydrazine derivatives. All the products have been characterized by IR and 1H-NMR spectral analysis. These derivatives showed potential cytotoxicity against brine shrimp nauplii than the ciprofloxacin.

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Author Biographies

Hari Pado Devnath, Department of Chemistry, Jahangirnagar University, Savar, Dhaka 1342

Lecturer

Md. Rabiul Islam, Department of Chemistry, Jahangirnagar University, Savar, Dhaka 1342

Professor

References

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Additional Files

Published

2010-05-29

How to Cite

Devnath, H. P., and M. R. Islam. “Synthesis of Some Pyrazolone Derivatives from Ciprofloxacin and Study of Their Cytotoxicity”. Bangladesh Journal of Pharmacology, vol. 5, no. 1, May 2010, pp. 30-33, doi:10.3329/bjp.v5i1.4693.

Issue

Section

Research Articles