Study of an endophytic fungus from Aquilaria malaccensis Lamk

Authors

  • Mohammad Shoeb Department of Chemistry, University of Dhaka, Dhaka 1000
  • Shahanara Begum Department of Chemistry, University of Dhaka, Dhaka 1000
  • Nilufar Nahar Department of Chemistry, University of Dhaka, Dhaka 1000

DOI:

https://doi.org/10.3329/bjp.v5i1.4687

Keywords:

Aquilaria malaccensis, Antibacterial, Coumarin, Endophytic, HPLC

Abstract

Nine endophytic fungal strains labeled as AL-1, AL-2, AS-1, AS-2, AS-3, AS-4, AR-1, AR-2 and AR-4 were isolated from the medicinal plant Aquilaria malaccensis Lamk. Three compounds 1,7-dihydroxy-3-methoxyanthraquinone, propyl p-methoxy phenyl ether and  6-methoxy-7-O-(p-methoxyphenyl)-coumarin were isolated from the ethyl acetate extract of the strain AL-2 by silica gel column chromatography and HPLC. The structures of isolated compounds were elucidated by spectroscopic techniques i.e. UV, IR, 1D and 2D NMR. Extracts of the strain AL-2 were assessed for antibacterial activities against Gram positive and Gram negative bacteria and general toxicity against brine shrimp lethality assay. The ethyl acetate extract showed only mild activity against two Gram positive bacteria (Bacillus cereus and Staphylococcus aureus).

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Author Biographies

Mohammad Shoeb, Department of Chemistry, University of Dhaka, Dhaka 1000

Associate Professor

Nilufar Nahar, Department of Chemistry, University of Dhaka, Dhaka 1000

Professor

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Additional Files

Published

2010-05-04

How to Cite

Shoeb, M., S. Begum, and N. Nahar. “Study of an Endophytic Fungus from Aquilaria Malaccensis Lamk”. Bangladesh Journal of Pharmacology, vol. 5, no. 1, May 2010, pp. 21-24, doi:10.3329/bjp.v5i1.4687.

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Section

Research Articles