In vitro antiviral activity of BanLec against herpes simplex viruses type 1 and 2


  • Arisha Taj Mahaboob Batcha Research Scholar, Department of Biochemistry, Dr.N.G.P Arts and Science College, Coimbatore, Tamil Nadu.
  • Ashish Wadhwani Assistant Professor and Head, 2Department of Pharmaceutical Biotechnology, JSS Academy of Higher Education & Research, JSS College of Pharmacy, Ooty-643001, Tamil Nadu, India.
  • Gowri Subramaniam Professor, Department of Biochemistry,Dr.N.G.P Arts and Science College, Coimbatore, Tamil Nadu. – 641048,India



Antiviral, BanLec, Herpes simplex, Musa paradisiaca


The present study evaluates the antiviral activity of banana lectin (BanLec) against herpes simplex virus type 1 and 2 (HSV-1 and HSV-2). Lectin was isolated from the ripen pulp of bananas (Musa paradisiaca). The study showed that lectin exhibited hemagglutination activity towards human erythrocytes A, B, AB and O group. The molecular weight of BanLec using SDS gel-electrophoresis was found to be 14,000-30,000 Da. Cytotoxicity of BanLec on the Vero cell lines showed an inhibitory concentration of 172.7 µg/mL. BanLec was virucidal and showed no cytotoxicity at the concentration tested. The lectin showed a dose-dependent antiviral activities, inhibiting HSV-1 by 16.0 µg/mL with selectivity index 10.8 and HSV-2 inhibition by 67.7 µg/mL with selectivity index 2.6. These results corroborate that BanLec could be a rich source of potential antiviral compound for HSV-1 when compared to HSV-2.

Video Clip of Methodology:

Hemaglutination test: 11 min 29 sec:   Click to watch


Download data is not yet available.
453 Read



How to Cite

Mahaboob Batcha, A. T., A. Wadhwani, and G. Subramaniam. “In Vitro Antiviral Activity of BanLec Against Herpes Simplex Viruses Type 1 and 2”. Bangladesh Journal of Pharmacology, vol. 15, no. 1, Mar. 2020, pp. 11-18, doi:10.3329/bjp.v15i1.42320.



Research Articles