Antimicrobial assay of endophytic fungi from Rumex madaio and chemical study of strain R1

  • Xuelian Bai College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou 310036, China
  • Ronglu Yu School of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China
  • Mingzhu Li School of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China
  • Huawei Zhang School of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China
Keywords: Antimicrobial, Endophytic fungi, Rumex madaio


In order to search more antimicrobial natural products for new drug discovery, bioassay and chemical investigation of endophytic strains from Rumex madaio were carried out. Six fungal strains (numbered as L1, L6, L9, L10, R1, R2) were successfully isolated and their antimicrobial effects on three human pathogens, Escherichia coli, Staphyloccocus aureus and Candida albicans, were evaluated. The results indicated that ethyl acetate extracts of fermentation broth of these strains had no potent antimicorbial activity against E. coli and C. albicans while strains L1 and R1 had stronger inhibitory effects on S. aureus. On basis of morphological characteristics and 18S rRNA sequence analysis, strains L1 and R1 were respectively classified as Colletotrichum and Fusarium geni. The chemical study of strain R1 led to isolation of two known antimicrobial agents, dibutyl phthalate (1) and beauvericin (2).

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Author Biography

Xuelian Bai, College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou 310036, China




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How to Cite
Bai, X., R. Yu, M. Li, and H. Zhang. “Antimicrobial Assay of Endophytic Fungi from Rumex Madaio and Chemical Study of Strain R1”. Bangladesh Journal of Pharmacology, Vol. 14, no. 3, Aug. 2019, pp. 129-35, doi:10.3329/bjp.v14i3.41598.
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