Salvia officinalis induces antidepressant-like effect, anxiolytic activity and learning improvement in hippocampal lesioned and intact adult rats

  • Zineb El Gabbas Laboratory of Pharmacology, Neurobiology and behavior, Semlalia Faculty of Sciences, cadiAyyad University, Marrakech, Morocco
  • Kenza Bezza Laboratory of Pharmacology, Neurobiology and behavior, Semlalia Faculty of Sciences, cadiAyyad University, Marrakech, Morocco
  • Jawad Laadraoui Laboratory of Pharmacology, Neurobiology and behavior, Semlalia Faculty of Sciences, cadiAyyad University, Marrakech, Morocco
  • Rachida Makbal Laboratory of Biotechnology, Protection and valorization of plant Resources, Phytochemistry and Pharmacology of Aromatic and Medicinal plants unit. Department of Biology, Faculty of Sciences Semlalia, Cadi AyyadUniversity,Marrakech, Morocco
  • Rachida Aboufatima Laboratory of GénieBiologique, Sultan MoulaySlimane University, Faculty of Sciences et Techniques, BeniMellal, Morocco
  • abderrahman Chait Laboratory of Pharmacology, Neurobiology and behavior, Semlalia Faculty of Sciences, cadiAyyad University, Marrakech, Morocco
Keywords: Anxiolytic, Antidepressant, Salvia officinalis


The anxiolytic and antidepressant like effects of Salvia officinalis extract (50, 100 and 200 mg/kg) were evaluated using marble burying, forced swimming and open-field tests in intact and hippocampal lesioned rats. Additionally, S. officinalis was evaluated on rat's memory using conditioned learning test. and we screened the methanolic extract for anti-oxidant activity, phytochemical and high performance liquid chromatography analyses. The administration of sage extract showed a significant reduction of immobility time in lesioned and intact animals during the forced swim test and anxiolytic effect in marble burying test. In the case of conditioned learning paradigm, memory enhancement was observed in sage treated group which indicates a cognition improvement. These activities seem to be related to the anti-oxidant capacity and the phytochemicals (phenolic, flavonoid, and tannin) detected into the extract of S. officinalis. The findings show that the methanolic extract of sage possess antidepressant-like effect, anxiolytic activity and also may contain bioactive compounds that stimulate learning in rat.


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Author Biographies

Kenza Bezza, Laboratory of Pharmacology, Neurobiology and behavior, Semlalia Faculty of Sciences, cadiAyyad University, Marrakech, Morocco

PhD Student

Jawad Laadraoui, Laboratory of Pharmacology, Neurobiology and behavior, Semlalia Faculty of Sciences, cadiAyyad University, Marrakech, Morocco

PhD Student

Rachida Makbal, Laboratory of Biotechnology, Protection and valorization of plant Resources, Phytochemistry and Pharmacology of Aromatic and Medicinal plants unit. Department of Biology, Faculty of Sciences Semlalia, Cadi AyyadUniversity,Marrakech, Morocco
PhD Student


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How to Cite
El Gabbas, Z., K. Bezza, J. Laadraoui, R. Makbal, R. Aboufatima, and abderrahman Chait. “Salvia Officinalis Induces Antidepressant-Like Effect, Anxiolytic Activity and Learning Improvement in Hippocampal Lesioned and Intact Adult Rats”. Bangladesh Journal of Pharmacology, Vol. 13, no. 4, Dec. 2018, pp. 367-78, doi:10.3329/bjp.v13i4.38375.
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