Role of poly (ADP-ribose) polymerase-1 and NF-kappaB as potential risk factor in the development of non-small cell lung cancer in Chinese individuals

Authors

  • Anguo Chen Department of Thoracic Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230022, China http://orcid.org/0000-0002-4366-8460
  • Zaicheng Yu Department of Thoracic Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230022, China http://orcid.org/0000-0002-8361-6964
  • Renquan Zhang Department of Thoracic Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230022, China http://orcid.org/0000-0001-5342-8498
  • Qihong Zhao Department of Food and Nutrition Hygiene, School of Public Health, Anhui Medical University, Hefei, Anhui, 230032, China
  • Jianjun Ge Department of Cardiovascular Surgery, The Anhui Provincial Hospital of Anhui Medical University, Hefei, Anhui 230001, China http://orcid.org/0000-0002-6131-2433

DOI:

https://doi.org/10.3329/bjp.v13i1.34031

Keywords:

Non-small cell lung cancer, NF-kappaB, Poly (ADP-ribose) polymerase-1

Abstract

The objective of this study was to evaluate the role of poly (ADP-ribose) polymerase-1 (PARP-1) and NF-kappaB as potential risk factor in the development of non-small cell lung cancer in Chinese individuals (n=110) of either gender aged <65 years. Healthy Chinese individuals (n=110) were included as control. Polymerase chain reaction was used to determine the role of PART-1 and NF-kappaB using plasma sample. The individuals with the GA genotype and carrier of G allele were at high-risk of non-small cell lung cancer. There was involvement of dL/is of the NF-kappaB in non-small cell lung cancer. Our study result suggests that the PARP-1 and NF-kappaB play an important role in development of non-small cell lung cancer in China.

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Published

2018-01-30

How to Cite

Chen, A., Z. Yu, R. Zhang, Q. Zhao, and J. Ge. “Role of Poly (ADP-Ribose) Polymerase-1 and NF-KappaB As Potential Risk Factor in the Development of Non-Small Cell Lung Cancer in Chinese Individuals”. Bangladesh Journal of Pharmacology, vol. 13, no. 1, Jan. 2018, pp. 30-34, doi:10.3329/bjp.v13i1.34031.

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Section

Research Articles