Antiarthritic efficacy of Clematis orientalis

Authors

  • Umme Habiba Hasan Laboratory of Cardiovascular Research and Integrative Pharmacology, Department of Pharmacology, Faculty of Pharmacy, University of Sargodha, Sargodha http://orcid.org/0000-0002-9983-9353
  • . Alamgeer Laboratory of Cardiovascular Research and Integrative Pharmacology, Department of Pharmacology, Faculty of Pharmacy, University of Sargodha, Sargodha http://orcid.org/0000-0003-4775-7337

DOI:

https://doi.org/10.3329/bjp.v13i2.33313

Keywords:

Antiarthritic, Clematis orientalis

Abstract

Clematis orientalis has been used traditionally to cure rheumatism, but its efficacy has not been scientifically explored in treating rheumatoid arthritis. The present study was designed to investigate the antiarthritic efficacy of C. orientalis using blockade of heat-induced protein alterations and HRBC membrane stabilization methods along with formaldehyde induced arthritis in rats. Aqueous ethanol (30:70) extract and various fractions (hexane, n-butanol and aqueous) produced concentration-dependent and significant (p<0.001) inhibition of protein (egg albumin and bovine serum albumin) denaturation and red blood cell membrane stabilization at 50-6400 ug/mL concentration. Similarly in formaldehyde induced arthritis plant extract and fractions revealed the considerable reduction in paw swelling and its diameter at doses of 50, 100 and 200 mg/kg with maximum (p<0.001) effect at the highest dose. Thus present findings imply that aqueous ethanol extract as well as different fractions of C. orientalis has noteworthy antiarthritic potential supporting its folkloric use in inflammatory arthritic conditions.

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Author Biography

. Alamgeer, Laboratory of Cardiovascular Research and Integrative Pharmacology, Department of Pharmacology, Faculty of Pharmacy, University of Sargodha, Sargodha

Assistant Professor

Additional Files

Published

2018-05-05

How to Cite

Hasan, U. H., and . Alamgeer. “Antiarthritic Efficacy of Clematis Orientalis”. Bangladesh Journal of Pharmacology, vol. 13, no. 2, May 2018, pp. 142-8, doi:10.3329/bjp.v13i2.33313.

Issue

Section

Research Articles