GC-MS profiling and antidepressant-like effect of the extracts of Hamelia patens in animal model

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DOI:

https://doi.org/10.3329/bjp.v12i4.32622

Keywords:

Antidepressant, Hamelia patens, GC-MS

Abstract

Hamelia patens is used in folk medicine in the treatment of nervous shock. The present study deals to evaluate the antidepressant-like effects of chloroform and methanol extracts of H. patens on the performance of male mice and GC-MS profiling of bioactive extract. Mice were given extracts orally in acute doses of 100 and 200 mg/kg daily for 7 days and then subjected to forced swim test, tail suspension test and open field test. Imipramine (10 mg/kg/day, p.o.) and  fluxetamine (10 mg/kg/day, p.o.) were used as the standard in forced swim test and tail suspension test  respectively. GC-MS profiling of chloroform extract was performed to find out the chemical constituents in bioactive fraction. After one-week treatment, the chloroform extract (100 and 200 mg/kg/day, p.o.) significantly reduced immobility time in forced swim test and tail suspension test (p<0.05). All extracts did not show any significant change in the locomotor activity in open field test. These data indicate that the extract of H. patens possesses antidepressant-like properties in mice without any significant effect on locomotor activity.

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Published

2017-11-15

How to Cite

Surana, A. R., and R. D. Wagh. “GC-MS Profiling and Antidepressant-Like Effect of the Extracts of Hamelia Patens in Animal Model”. Bangladesh Journal of Pharmacology, vol. 12, no. 4, Nov. 2017, pp. 410-6, doi:10.3329/bjp.v12i4.32622.

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Section

Research Articles