Taraxerol protects the human hepatic L02 cells from hydrogen peroxide-induced apoptosis

Authors

  • Xiang-Yang Yao School of Food and Biology Engineering, Bengbu University, Bengbu 233030 http://orcid.org/0000-0003-2956-6713
  • Qin Bai School of Food and Biology Engineering, Bengbu University, Bengbu 233030

DOI:

https://doi.org/10.3329/bjp.v12i2.30985

Keywords:

Apoptosis, Human hepatic L02 cell, Hydrogen peroxide, Taraxerol

Abstract

Taraxerol is known to exhibit anti-inflammatory and anti-cancer activity. However, cytoprotective effect of taraxerol on hepatocytes has not been reported. In the present study, we investigated the hepatoprotective effect of taraxerol in the human hepatic L02 cells injured by hydrogen peroxide (H2O2). Taraxerol decreased H2O2-induced cell viability loss and lactate dehydrogenase release. Taraxerol also inhibited H2O2-induced cell apoptosis. Further, taraxerol attenuated H2O2-induced increase in cleaved-caspase-3 and cleaved-PARP. H2O2-activated p38 and JNK were also inhibited by taraxerol. These data suggest that taraxerol could protect the L02 cells against H2O2-induced apoptosis via suppression of p38 and JNK. Taraxerol may be an effective protective agent against oxidative stress-induced liver injury.

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Published

2017-04-20

How to Cite

Yao, X.-Y., and Q. Bai. “Taraxerol Protects the Human Hepatic L02 Cells from Hydrogen Peroxide-Induced Apoptosis”. Bangladesh Journal of Pharmacology, vol. 12, no. 2, Apr. 2017, p. Available Online: Apr 20, 2017, doi:10.3329/bjp.v12i2.30985.

Issue

Section

Research Articles