Synthesis, characterization and evaluation of antidiabetic activity of novel indoline derivatives

Authors

  • Dhineshkumar Manoharan Department of Chemistry, Government College of Engineering, Salem, Tamil Nadu http://orcid.org/0000-0001-7595-8078
  • Kannan Kulanthai Department of Chemistry, Government College of Engineering, Salem, Tamil Nadu http://orcid.org/0000-0003-1325-3608
  • Gnanavel Sadhasivam Department of Chemistry, Government College of Engineering, Salem, Tamil Nadu http://orcid.org/0000-0002-2771-4279
  • Vijayan Raji Laboratory of Bioprocess and Genetic Engineering, Department of Biochemistry, Periyar University, Salem, Tamil Nadu
  • Paalvannan Thayumanavan Laboratory of Bioprocess and Genetic Engineering, Department of Biochemistry, Periyar University, Salem, Tamil Nadu

DOI:

https://doi.org/10.3329/bjp.v12i2.30872

Keywords:

?-Amylase, Antidiabetic, Indoline, 1H-NMR

Abstract

Series of indoline derivatives were synthesized using N-(4-aminophenyl)indoline-1-carbothiamide as a precursor. The confirmation of synthesized compounds was done by 1H-NMR, 13C-NMR, LC-MS (ESI) and FT-IR. In vitro antidiabetic activity of synthesized indoline derivatives were examined by standard ?-amylase inhibition assay. The compounds 4a (IC50 = 52.1 µg/mL) and 4b (IC50 = 57.7 µg/mL) showed potent ?-amylase inhibition activity. The compounds 3a (IC50 = 62.2 µg/mL) and 3b (IC50 = 60.7 µg/mL) showed moderate antidiabetic activity.

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Author Biographies

Dhineshkumar Manoharan, Department of Chemistry, Government College of Engineering, Salem, Tamil Nadu

Research Scholar

Paalvannan Thayumanavan, Laboratory of Bioprocess and Genetic Engineering, Department of Biochemistry, Periyar University, Salem, Tamil Nadu

Assistant Professor

Mobile: 0091-9894280618; 0091-7598480618

 

Published

2017-05-20

How to Cite

Manoharan, D., K. Kulanthai, G. Sadhasivam, V. Raji, and P. Thayumanavan. “Synthesis, Characterization and Evaluation of Antidiabetic Activity of Novel Indoline Derivatives”. Bangladesh Journal of Pharmacology, vol. 12, no. 2, May 2017, pp. 167-72, doi:10.3329/bjp.v12i2.30872.

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Section

Research Articles