Synthesis, characterization and evaluation of antidiabetic activity of novel indoline derivatives

Authors

  • Dhineshkumar Manoharan Department of Chemistry, Government College of Engineering, Salem, Tamil Nadu http://orcid.org/0000-0001-7595-8078
  • Kannan Kulanthai Department of Chemistry, Government College of Engineering, Salem, Tamil Nadu http://orcid.org/0000-0003-1325-3608
  • Gnanavel Sadhasivam Department of Chemistry, Government College of Engineering, Salem, Tamil Nadu http://orcid.org/0000-0002-2771-4279
  • Vijayan Raji Laboratory of Bioprocess and Genetic Engineering, Department of Biochemistry, Periyar University, Salem, Tamil Nadu
  • Paalvannan Thayumanavan Laboratory of Bioprocess and Genetic Engineering, Department of Biochemistry, Periyar University, Salem, Tamil Nadu

DOI:

https://doi.org/10.3329/bjp.v12i2.30872

Keywords:

?-Amylase, Antidiabetic, Indoline, 1H-NMR

Abstract

Series of indoline derivatives were synthesized using N-(4-aminophenyl)indoline-1-carbothiamide as a precursor. The confirmation of synthesized compounds was done by 1H-NMR, 13C-NMR, LC-MS (ESI) and FT-IR. In vitro antidiabetic activity of synthesized indoline derivatives were examined by standard ?-amylase inhibition assay. The compounds 4a (IC50 = 52.1 µg/mL) and 4b (IC50 = 57.7 µg/mL) showed potent ?-amylase inhibition activity. The compounds 3a (IC50 = 62.2 µg/mL) and 3b (IC50 = 60.7 µg/mL) showed moderate antidiabetic activity.

Video Clip of Methodology:

19 min 21 sec   Full Screen   Alternate

Downloads

Download data is not yet available.
Abstract
2
Download
2 Read
2

Author Biographies

Dhineshkumar Manoharan, Department of Chemistry, Government College of Engineering, Salem, Tamil Nadu

Research Scholar

Paalvannan Thayumanavan, Laboratory of Bioprocess and Genetic Engineering, Department of Biochemistry, Periyar University, Salem, Tamil Nadu

Assistant Professor

Mobile: 0091-9894280618; 0091-7598480618

 

Downloads

Additional Files

Published

2017-05-20

How to Cite

Manoharan, D., K. Kulanthai, G. Sadhasivam, V. Raji, and P. Thayumanavan. “Synthesis, Characterization and Evaluation of Antidiabetic Activity of Novel Indoline Derivatives”. Bangladesh Journal of Pharmacology, vol. 12, no. 2, May 2017, pp. 167-72, doi:10.3329/bjp.v12i2.30872.

Issue

Vol. 12 No. 2 (2017)

Section

Research Articles

License

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).