L-Carnitine supplementation ameliorates serum tumor necrosis factor-alpha and matrix metalloproteinase-3 in knee osteoarthritis women





Knee, L-Carnitine, Clinical trial, Matrix metalloproteinase-3, Osteoarthritis, Tumor necrosis factor-alpha


Seventy-two females with mild to moderate knee osteoarthritis were included in this randomized double-blind placebo-controlled study. Patients in the intervention group (n=36) received L-carnitine supplement (750 mg/day) for two months. L-Carnitine supplementation led to decrease in serum TNF-? and MMP-3 levels significantly in comparison with the baseline (p<0.001 and p<0.001, respectively) and placebo group (p<0.001 and p=0.03, respectively). In addition, physicians global assessment of the severity of osteoarthritis decreased significantly in the L-carnitine group (p<0.001) and placebo group (p=0.012) after supplementation. At the end of the study, a significant difference was observed between the two groups for mean physicians global assessment of the severity of osteoarthritis (p<0.001), adjusted for baseline values and duration of osteoarthritis. L-Carnitine supplementation has beneficial effects in reducing inflammatory biomarkers in knee osteoarthritis patients which subsequently leads to the alleviation of disease symptoms.


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How to Cite

Mahdavi, R., S. Kolahi, V. E. Attari, and A. M. Mahdavi. “L-Carnitine Supplementation Ameliorates Serum Tumor Necrosis Factor-Alpha and Matrix Metalloproteinase-3 in Knee Osteoarthritis Women”. Bangladesh Journal of Pharmacology, vol. 12, no. 1, Mar. 2017, pp. 28-34, doi:10.3329/bjp.v12i1.30417.



Clinical Trial