Antibacterial and anti-hemolytic activity of tannins from Pimenta dioica against methicillin resistant Staphylococcus aureus

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DOI:

https://doi.org/10.3329/bjp.v12i1.29735

Keywords:

Antibacteria, Anti-hemolytic, Methicillin resistant Staphylococcus aureus, Pimenta dioica, Tannin

Abstract

High rate of resistance among Staphylococcus infection initiates scientists to discover new antibiotics. The objective of this study is to determine the effect of tannins isolated from the Pimenta dioica leaves on Staphylococcus aureus and methicillin resistant S. aureus as well as to evaluate their effect on hemolysin production. The antimicrobial activity of 4,6-(S)-hexahydroxydiphenoyl-(?/?)-D-glucopyranose and casuarinin, pedunculagin and nilocitin tannins from P. dioica was examined using agar diffusion method. Moreover, minimum inhibitory concentrations were evaluated by microtiter plate assay method. Pedunculagin and nilocitin exhibited antibacterial and anti-hemolytic effect against S. aureus. This will open the era for in vivo assessment of such compounds for clinical applications.

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Author Biographies

Fatma Moharram, Department of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Pharmacy, Taibah University, Al Madinah Al Munawarah 30078

Professor

Ola Abd El-Rahman, Department of Microbiology and Immunology, Faculty of Pharmacy, Azhar University

Associate Professor

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Published

2017-03-03

How to Cite

Al-Harbi, R., R. Al-wegaisi, F. Moharram, M. Shaaban, and O. Abd El-Rahman. “Antibacterial and Anti-Hemolytic Activity of Tannins from Pimenta Dioica Against Methicillin Resistant Staphylococcus Aureus”. Bangladesh Journal of Pharmacology, vol. 12, no. 1, Mar. 2017, pp. 63-68, doi:10.3329/bjp.v12i1.29735.

Issue

Vol. 12 No. 1 (2017)

Section

Research Articles

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