Antidiarrheal activity of ethanolic bark extract of <i>Mitragyna diversifolia</i>

  • - Jebunnessa Department of Botany, University of Chittagong, Chittagong 4331
  • Shaikh Bokhtear Uddin Department of Botany, University of Chittagong, Chittagong 4331
  • M. Mahabub-Uz-Zaman BCSIR Laboratories, Chittagong, Chittagong 4220
  • Rasheda Akter BCSIR Laboratories, Chittagong, Chittagong 4220
  • Nazim Uddin Ahmed BCSIR Laboratories, Chittagong, Chittagong 4220
Keywords: Antidiarrheal activity, Barium sulfate milk, Castor oil, Mitragyna diversifolia

Abstract

The ethanolic bark extract of Mitragyna diversifolia showed significant (p<0.05) antidiarrheal activity on gastrointestinal motility with barium sulfate milk model and castor oil- induced diarrheal model in rats. These result obtained revealed that the bark extract possess pharmacological activity against diarrhea and may possibly explain the use of the plant in traditional medicine.

Downloads

Download data is not yet available.
Abstract
748
Download
806 Read
55

Author Biography

- Jebunnessa, Department of Botany, University of Chittagong, Chittagong 4331
Scientific Officer

References

Atta AH, Mouneir SM. Antidiarrheal activity of some Egyptian medicinal plant extracts. J Ethnopharmacol. 2004; 92: 303-09.

Carlos CC, Saniel MC. Etiology and epidemiology of diarrhea. Phillips J Microbio Infect Dis. 1990; 19: 51-53.

Chatterjee TK. Handbook on laboratory mice and rats. 1st ed. Kolkata, Department of Pharmaceutical Technology, Jadavpur University, 1993, p 157.

Gaginella TS, Phillips SF. Ricinoleic acid: Current view of ancient oil. Dig Dis Sci. 1975; 23: 1171-77.

Luderer JR, Dermers IM, Hayes AT. Advances in prostaglandin and thromboxane research. New York, Raven Press, 1980, pp 1633-38.

Mekeon TA, Lin A, Stafford AE. Biosynthesis of ricinoleate in castor oil. Adv Exp Med Biol. 1999, pp. 46437-47.

Ojewole JAO. Evaluation of antidiarrheal, anti-inflammatory and antidiabetic properties of Sclerocarya birrea (A. Rich.) Hochst. stem bark aqueous extract in mice and rats. Phytotherapy Res. 2004; 18: 601-08.

Published
2009-10-13
How to Cite
Jebunnessa, -, S. Uddin, M. Mahabub-Uz-Zaman, R. Akter, and N. Ahmed. “Antidiarrheal Activity of Ethanolic Bark Extract of <i>Mitragyna Diversifolia</I&gt;”. Bangladesh Journal of Pharmacology, Vol. 4, no. 2, Oct. 2009, pp. 144-6, doi:10.3329/bjp.v4i2.2801.
Section
Research Articles