Antidiarrheal activity of ethanolic bark extract of <i>Mitragyna diversifolia</i>
The ethanolic bark extract of Mitragyna diversifolia showed significant (p<0.05) antidiarrheal activity on gastrointestinal motility with barium sulfate milk model and castor oil- induced diarrheal model in rats. These result obtained revealed that the bark extract possess pharmacological activity against diarrhea and may possibly explain the use of the plant in traditional medicine.
Atta AH, Mouneir SM. Antidiarrheal activity of some Egyptian medicinal plant extracts. J Ethnopharmacol. 2004; 92: 303-09.
Carlos CC, Saniel MC. Etiology and epidemiology of diarrhea. Phillips J Microbio Infect Dis. 1990; 19: 51-53.
Chatterjee TK. Handbook on laboratory mice and rats. 1st ed. Kolkata, Department of Pharmaceutical Technology, Jadavpur University, 1993, p 157.
Gaginella TS, Phillips SF. Ricinoleic acid: Current view of ancient oil. Dig Dis Sci. 1975; 23: 1171-77.
Luderer JR, Dermers IM, Hayes AT. Advances in prostaglandin and thromboxane research. New York, Raven Press, 1980, pp 1633-38.
Mekeon TA, Lin A, Stafford AE. Biosynthesis of ricinoleate in castor oil. Adv Exp Med Biol. 1999, pp. 46437-47.
Ojewole JAO. Evaluation of antidiarrheal, anti-inflammatory and antidiabetic properties of Sclerocarya birrea (A. Rich.) Hochst. stem bark aqueous extract in mice and rats. Phytotherapy Res. 2004; 18: 601-08.
Copyright (c) 2009 Jebunnessa, Shaikh Bokhtear Uddin, M. Mahabub-Uz-Zaman, Rasheda Akter, Nazim Uddin Ahmed
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