Enhancement of cognitive performance in mice and in vitro acetylcholinesterase inhibitory activity of 3,3’,4’,5,7-pentahydroxyflavone isolated from Cadaba indica

  • Sundaram Dhivya Department of Pharmaceutical Technology, Centre for Excellence in Nanobio Translational Research Center, Anna University, Bharathidasan Institute of Technology Campus, Tiruchirappalli, Tamil Nadu http://orcid.org/0000-0002-4220-4381
  • Subbiah Latha Department of Pharmaceutical Technology, Centre for Excellence in Nanobio Translational Research Center, Anna University, Bharathidasan Institute of Technology Campus, Tiruchirappalli, Tamil Nadu http://orcid.org/0000-0001-5054-6296
  • Palanisamy Selvamani Department of Pharmaceutical Technology, Centre for Excellence in Nanobio Translational Research Center, Anna University, Bharathidasan Institute of Technology Campus, Tiruchirappalli, Tamil Nadu http://orcid.org/0000-0001-6751-7133
Keywords: Acetylcholinesterase, Cadaba indica, Cognitive performance, Mice, Pentahydroxyflavone

Abstract

Cadaba indica, a component of traditional siddha medicine, is used for the therapy of gonorrhea, inflammation, eczema etc. The present study shows that it exhibited acetylcholinesterase inhibitory activity (up to 81.5 ± 1.5%) at the concentration of 3 mg/mL, with the IC50 value of 1.8 mg/mL. Furthermore, the ethanol extract of C. indica therapy at a dose of 100 mg/kg p.o significantly ameliorated the cognitive impaired mice in Y-maze task. The active ingredient was identified as 3,3,4,5,7-pentahydroxyflavone. The above results suggest that C. indica would be a potential natural therapeutic remedy for cognitive disorders mediated by cholinergic dysfunction.

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Author Biographies

Sundaram Dhivya, Department of Pharmaceutical Technology, Centre for Excellence in Nanobio Translational Research Center, Anna University, Bharathidasan Institute of Technology Campus, Tiruchirappalli, Tamil Nadu
Senior Research Fellow
Subbiah Latha, Department of Pharmaceutical Technology, Centre for Excellence in Nanobio Translational Research Center, Anna University, Bharathidasan Institute of Technology Campus, Tiruchirappalli, Tamil Nadu
Assistant Professor
Palanisamy Selvamani, Department of Pharmaceutical Technology, Centre for Excellence in Nanobio Translational Research Center, Anna University, Bharathidasan Institute of Technology Campus, Tiruchirappalli, Tamil Nadu
Assistant Professor

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Published
2016-11-12
How to Cite
Dhivya, S., S. Latha, and P. Selvamani. “Enhancement of Cognitive Performance in Mice and in Vitro Acetylcholinesterase Inhibitory Activity of 3,3’,4’,5,7-Pentahydroxyflavone Isolated from Cadaba Indica”. Bangladesh Journal of Pharmacology, Vol. 11, no. 4, Nov. 2016, pp. 886-93, doi:10.3329/bjp.v11i4.28000.
Section
Research Articles