Mentha longifolia lowers blood pressure in anesthetized rats through multiple pathways

  • Abdul Jabbar Shah COMSATS Institute of Information Technology
  • Ishfaq Ali Bukhari Department of Pharmacology, College of Medicine and King Khalid University Hospitals, King Saud University, Riyadh
  • Anwarul Hassan Gilani Department of Pharmacology, Vice chair for research and graduate studies, Department of Biological and Biomedical Sciences, Aga Khan University, Karachi
Keywords: Anesthesia, Blood pressure, Mentha longifolia, Rat

Abstract

This study was aimed to investigate the effect of the extract of Mentha longifolia on blood pressure and the possible mechanisms. In anesthetized rats, the crude extract of M. longifolia and aqueous and chloroform fractions caused a dose-dependent fall in mean arterial pressure. Atropine pretreatment abolished the effect of extract and aqueous fraction but did not change that of chloroform fraction. In rabbit aortic rings, crude extract relaxed phenylephrine (1 µM) and high K+ (80 mM) pre-contractions. Chloroform fraction was more potent against high K+, similar to verapamil and caused a rightward shift in the Ca++ concentration-response curves. Aqueous fraction partially relaxed high K+ pre-contractions. In rat aortic rings, crude extract and aqueous fraction-induced endothelium-dependent atropine-sensitive vasodilator effect. Extract and fractions also relaxed high K+ precontractions. In guinea-pig atrial strips, crude extract and chloroform fraction suppressed force and rate of contractions, similar to verapamil. In conclusion, M. longifolia lowers blood pressure through Ca++ channel blockade and atropine-sensitive-NO pathway.

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Experiment using aorta: 2 min 35 sec  Full Screen   Alternative

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Author Biographies

Abdul Jabbar Shah, COMSATS Institute of Information Technology

Associate Professor

Ishfaq Ali Bukhari, Department of Pharmacology, College of Medicine and King Khalid University Hospitals, King Saud University, Riyadh
Assistant Professor 

Anwarul Hassan Gilani, Department of Pharmacology, Vice chair for research and graduate studies, Department of Biological and Biomedical Sciences, Aga Khan University, Karachi

Professor and 

Chairman, Pakistan Council for Science and Technology
Government of Pakistan

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Published
2016-10-01
How to Cite
Shah, A., I. Bukhari, and A. Gilani. “Mentha Longifolia Lowers Blood Pressure in Anesthetized Rats through Multiple Pathways”. Bangladesh Journal of Pharmacology, Vol. 11, no. 4, Oct. 2016, pp. 784-92, doi:10.3329/bjp.v11i4.27340.
Section
Research Articles