Antidepressant effects of Mentha pulegium in mice

Zahra Rabiei, Mostafa Gholami, Mahmoud Rafieian-Kopaei

Abstract

The aim of this study is to investigate the antidepressant effects of Mentha pulegium essential oil in BALB/c mice. Six experimental groups (7 mice each) were used. Forced swim test was performed 30 min after essential oil injection. In the groups receiving M. pulegium essential oil (50, 75 and 100 mg/kg), immobility duration significantly decreased compared to the control group. M. pulegium (50 and 75 mg/kg) resulted in significant decrease in nitrate/nitrite content in serum compared to the control group. M. pulegium essential oil antidepressant effect that may be due to the inhibition of oxidative stress.  The results showed that decrease in nitrate/nitrite content in serum and high anti-oxidant effects of M. pulegium essential oil.

Video Clip of Methodology:

Immobility in Forced Swim Test: 13 sec   Full Screen   Alternate

Mobility in Forced Swim Test: 19 sec   Full Screen   Alternate

Keywords

Antidepressant; Depression; Forced swimming test; Mentha pulegium; Mice

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DOI: http://dx.doi.org/10.3329/bjp.v11i3.27318

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Copyright (c) 2016 Zahra Rabiei, Mostafa Gholami, Mahmoud Rafieian-kopaei

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Bangladesh Journal of Pharmacology (Bangladesh J Pharmacol) is a single-blinded peer-reviewed, video component, open access official publication of the Bangladesh Pharmacological Society (BDPS). eISSN: 1991-0088. For contact: Editor-In-Chief