Angiogenesis and expression of vascular endothelial growth factor and endostatin protein in myocardial infarction rat model

Authors

  • Chenglong Zheng Beijing University of Chinese Medicine, 11 Bei San Huan Dong Lu, ChaoYang District, Beijing 100029 and Beijing Drum Tower Hospital of Traditional Chinese Medicine,13 Dou Fu Chi Hutong, Dongcheng District, Beijing 10009
  • Panchu Yang Comprehensive Section, Liangxiang Hospital, Afflicated Hospital of Yanjing Medical College of Capital University of Medical Science, No. 45, Gongchen North Street, Liangxiang Country, Fangshan District, Beijing 102401
  • Lu Zhang Beijing University of Chinese Medicine, 11 Bei San Huan Dong Lu, ChaoYang District, Beijing 100029
  • Zhiyong Wang Beijing University of Chinese Medicine, 11 Bei San Huan Dong Lu, ChaoYang District, Beijing 100029
  • Kun Chen Beijing University of Chinese Medicine, 11 Bei San Huan Dong Lu, ChaoYang District, Beijing 100029
  • Yue Lan Department of Traditional Chinese Medicine of Fuwai Hospital, CAMS and PUMC,137 Bei Li Shi Lu, Xicheng District, Beijing 10009
  • Xing Zhai Beijing University of Chinese Medicine, 11 Bei San Huan Dong Lu, ChaoYang District, Beijing 100029
  • Kun Huang Beijing University of Chinese Medicine, 11 Bei San Huan Dong Lu, ChaoYang District, Beijing 100029
  • Shuwen Guo Beijing University of Chinese Medicine, 11 Bei San Huan Dong Lu, ChaoYang District, Beijing 100029

DOI:

https://doi.org/10.3329/bjp.v11i0.26416

Keywords:

Angiogenesis, Endostatin protein, Myocardial infarction, Vascular endothelial growth factor

Abstract

The aim of this study was the effects of supplementing qi and herbs that promote neovascularization on angiogenesis and expressions of vascular endothelial growth factor and endostatin protein in experimentally induced acute myocardial infarction in rats. Left anterior descending coronary artery was ligated to establish the acute myocardial infarction model. Microvascular vascular count and expressions of vascular endothelial growth factor and endostatin protein were detected and indexes were detected at 7th, 14th and 28th day. The results showed large doses of qi herbs combined with small doses of activating herbs are superior to other groups in promoting the angiogenesis, increasing vascular endothelial growth factor protein expressions and reducing endostatin protein expressions. It also showed that there was a dose-response effect of supplementing qi and activating blood circulation herbs promoting angiogenesis. The mechanism of supplementing qi and activating blood circulation herbs and combination of both promoted angiogenesis due to possibly to increased vascular endothelial growth factor protein expressions and reduced endostatin protein expressions.

 

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Author Biography

Chenglong Zheng, Beijing University of Chinese Medicine, 11 Bei San Huan Dong Lu, ChaoYang District, Beijing 100029 and Beijing Drum Tower Hospital of Traditional Chinese Medicine,13 Dou Fu Chi Hutong, Dongcheng District, Beijing 10009

 

 

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Published

2016-02-13

How to Cite

Zheng, C., P. Yang, L. Zhang, Z. Wang, K. Chen, Y. Lan, X. Zhai, K. Huang, and S. Guo. “Angiogenesis and Expression of Vascular Endothelial Growth Factor and Endostatin Protein in Myocardial Infarction Rat Model”. Bangladesh Journal of Pharmacology, vol. 11, no. S1, Feb. 2016, pp. S1-S7, doi:10.3329/bjp.v11i0.26416.

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Research Articles