Effects of Alchemilla mollis and Alchemilla persica on the wound healing process

Authors

  • Burçin Ergene Öz Department of Pharmacognosy, Faculty of Pharmacy, Ankara University, 06100, Ankara http://orcid.org/0000-0001-6927-6652
  • Mert Ilhan Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Etiler 06330, Ankara
  • Serkan Ozbilgin Department of Pharmacognosy, Faculty of Pharmacy, Ankara University, 06100, Ankara http://orcid.org/0000-0002-3945-6756
  • Esra Küpeli Akkol Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Etiler 06330, Ankara
  • Özlem Bahadir Acikara
  • Gülçin Saltan Department of Pharmacognosy, Faculty of Pharmacy, Ankara University, 06100, Ankara
  • Hikmet Keles Department of Pathology, Faculty of Veterinary Medicine, Afyon Kocatepe University, 03200, Afyonkarahisar
  • Ipek Süntar Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Etiler 06330, Ankara

DOI:

https://doi.org/10.3329/bjp.v11i3.26024

Keywords:

Alchemilla mollis, Alchemilla persica, Anti-inflammatory, Wound healing

Abstract

Alchemilla mollis, is used in traditional medicine for the treatment of wounds and excessive menstruation. Aqueous methanol extracts of A. mollis and A. persica were evaluated for wound healing acivity by using linear incision and circular excision wound models along with hydroxyproline estimation and histopathological analysis. Anti-inflammatory effect was determined according to Whittle method. The extracts prepared from the aerial parts of A. mollis and A. persica exerted significant wound healing activity with the tensile strength values of 39.3% and 33.3%, respectively, and with the contraction values of 51.4% and 43.5%, respectively. Hydroxyproline estimation and histopathological analysis also confirmed the results. The extracts of A. mollis and A. persica showed significant anti-inflammatory activity with the values of 30.6% and 26.6% respectively. These results showed that A. mollis and A. persica possess significant wound healing and anti-inflammatory activities.

Video Clip of Methodology:

Circular excision wound model: 2 min   Click to watch

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Author Biography

Ipek Süntar, Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Etiler 06330, Ankara

Associate Professor

Published

2016-06-02

How to Cite

Ergene Öz, B., M. Ilhan, S. Ozbilgin, E. Küpeli Akkol, Özlem Bahadir Acikara, G. Saltan, H. Keles, and I. Süntar. “Effects of Alchemilla Mollis and Alchemilla Persica on the Wound Healing Process”. Bangladesh Journal of Pharmacology, vol. 11, no. 3, June 2016, pp. 577-84, doi:10.3329/bjp.v11i3.26024.

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Section

Research Articles