Degradation behavior of theophylline/chitosan/β-cyclodextrin microspheres for pulmonary drug delivery

Authors

  • Li Wang Affiliated Reproductive Medicine Center, Weifang Medical University, Weifang 261042, Shandong
  • Tingting Yang Department of Pharmaceutics, College of Pharmacy, Weifang Medical University, Weifang 261053
  • Weiping Ju Department of Neurology, Wendeng Central Hospital of Weihai, Affiliated Hospital of Weifang Medical University, Wendeng 266400, Shandong
  • Ming Ren Affiliated Hospital of Weifang Medical University, Weifang 261053
  • Zhanqin Feng Department of Pharmaceutics, College of Pharmacy, Weifang Medical University, Weifang 261053
  • Zengjuan Zheng Department of Pharmaceutics, College of Pharmacy, Weifang Medical University, Weifang 261053
  • Zhenbo Hu Affiliated Hospital of Weifang Medical University, Weifang 261053
  • Yuqing Liu Department of Pathology, College of Basic Medicine, Weifang Medical University, Weifang 261053
  • Weifen Zhang Department of Pharmaceutics, College of Pharmacy, Weifang Medical University, Weifang 261053

DOI:

https://doi.org/10.3329/bjp.v11iS1.25634

Keywords:

Chitosan, ?-Cyclodextrin, Pulmonary drug delivery, Theophylline

Abstract

To evaluate the degradation behavior of theophylline/chitosan/β-cyclodextrin microspheres, we performed both in vitro study by putting the microspheres in phosphate buffered saline or in phosphate buffer saline with enzyme and in vivo study by implanting the microspheres into the back of male Sprague-Dawley rats. The results showed that microspheres were degraded in enzymatic hydrolysis and phosphate buffer saline, which were degraded faster in 0.2 mg/mL lysozyme than in phosphate buffer saline. The morphology of microspheres in phosphate buffer saline and enzyme solution developed rough surfaces, and showed irregular shape and pores after 8 weeks. The microspheres were degraded in vivo within 8 weeks with irregular, sheet, porous morphology, and the diameters were smaller than 5 ?m. These results indicated that the theophylline/chitosan/β-cyclodextrin microspheres had a good degradation both in vitro and in vivo which can be used as a pulmonary drug delivery carrier.

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Published

2016-03-06

How to Cite

Wang, L., T. Yang, W. Ju, M. Ren, Z. Feng, Z. Zheng, Z. Hu, Y. Liu, and W. Zhang. “Degradation Behavior of theophylline/Chitosan/β-Cyclodextrin Microspheres for Pulmonary Drug Delivery”. Bangladesh Journal of Pharmacology, vol. 11, no. S1, Mar. 2016, pp. S116-S122, doi:10.3329/bjp.v11iS1.25634.

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Section

Research Articles