Studies on the antidiabetic effects of Mangifera indica stem-barks and leaves on nondiabetic, type 1 and type 2 diabetic model rats


  • Amrita Bhowmik Dept of Biochemistry and Molecular Biology, Jahangirnagar University
  • Liakot Ali Khan Dept of Biochemistry and Molecular Biology, Jahangirnagar University
  • Masfida Akhter Dept of Pharmacology, BIRDEM, Dhaka
  • Begum Rokeya Dept of Pharmacology, BIRDEM



Antidiabetic, Mangifera indica, Glucose, Prandial, Rat


Mangifera indica Linn, locally known as mango tree has been claimed to possess antidiabetic properties by many investigators. The present study was undertaken to screen the hypoglycemic and antihyperglycemic activity of both ethanol and water extracts of leaves and stem-barks of M. indica in nondiabetic and diabetic model rats in different prandial state. The results showed that all of the extracts had significant antihyperglycemic effect in type 2 diabetic model rats when fed simultaneously with glucose load (p<0.05-0.01; p<0.005-0.001). Moreover, the ethanol extract of stem-barks showed significant antihyperglycemic effect when the extract was fed 30 min prior to the glucose load (p<0.01). Investigations were carried out to evaluate the effect of M. indica on glucose absorption using a rat intestinal preparation in situ. The ethanol extracts of stem-barks reduced glucose absorption gradually during the whole perfusion period in type 2 diabetic rats.


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Author Biographies

Amrita Bhowmik, Dept of Biochemistry and Molecular Biology, Jahangirnagar University

Research Fellow

Liakot Ali Khan, Dept of Biochemistry and Molecular Biology, Jahangirnagar University


Masfida Akhter, Dept of Pharmacology, BIRDEM, Dhaka

Research fellow

Begum Rokeya, Dept of Pharmacology, BIRDEM



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How to Cite

Bhowmik, A., L. A. Khan, M. Akhter, and B. Rokeya. “Studies on the Antidiabetic Effects of Mangifera Indica Stem-Barks and Leaves on Nondiabetic, Type 1 and Type 2 Diabetic Model Rats”. Bangladesh Journal of Pharmacology, vol. 4, no. 2, May 2009, pp. 110-4, doi:10.3329/bjp.v4i2.2488.



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