Inhibition of cell proliferation by 2-fluorobenzaldehyde retinoic acid conjugate through suppression of STAT3 activation in human glioma cells

Authors

  • Ji-Heng Hao Department of Neurosurgery, Qilu Hospital of Shandong University, Jinan City 250012, Shandong Province
  • Dian-Feng Hu Department of Neurosurgery, Liaocheng People?s Hospital and Liaocheng Clinical School of Taishan Medical University, Liaocheng City 252000, Shandong Province
  • Li-Mei Mao Department of Health, Liaocheng People?s Hospital and Liaocheng Clinical School of Taishan Medical University, Liaocheng City 252000, Shandong Province
  • Shi-Gang Zhang Department of Neurosurgery, Liaocheng People?s Hospital and Liaocheng Clinical School of Taishan Medical University, Liaocheng City 252000, Shandong Province
  • Ji-Yue Wang Department of Neurosurgery, Liaocheng People?s Hospital and Liaocheng Clinical School of Taishan Medical University, Liaocheng City 252000, Shandong Province
  • Gang Li Department of Neurosurgery, Qilu Hospital of Shandong University, Jinan City 250012, Shandong Province

DOI:

https://doi.org/10.3329/bjp.v10i4.24165

Keywords:

2-Fluorobenzaldehyde retinoic acid conjugate, Cell proliferation, Human glioma cell, STAT3 activation

Abstract

The present study was performed to investigate the effect of 2-fluorobenzaldehyde retinoic acid conjugate on activation of STAT3 pathway in human glioma cells. The results revealed that the compound exhibited inhibitory effect on the activation of STAT3 induced constitutively and by interleukin-6. The inhibitory effect on STAT3 activation was found to be concentration- and time-dependent. In U373 glioma cells, 2-fluorobenzaldehyde retinoic acid conjugate treatment caused a significant enhancement in the expression of proapoptotic proteins like Bax and Bak. Its treatment inhibited the expression of genes including, cyclin D1, Bcl-2, Bcl-xL, survivin, Mcl-1, and vascular endothelial growth factor (VEGF) in U373 glioma cells. Furthermore, the conjugate inhibited proliferation, induced apoptosis and caused accumulation of cells in G1-G0 phase of cell cycle. Thus, 2-fluorobenzaldehyde retinoic acid conjugate acts as a potent inhibitor of STAT3 activation that can be promising importance for the prevention and treatment of gliomas.

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Published

2015-11-22

How to Cite

Hao, J.-H., D.-F. Hu, L.-M. Mao, S.-G. Zhang, J.-Y. Wang, and G. Li. “Inhibition of Cell Proliferation by 2-Fluorobenzaldehyde Retinoic Acid Conjugate through Suppression of STAT3 Activation in Human Glioma Cells”. Bangladesh Journal of Pharmacology, vol. 10, no. 4, Nov. 2015, pp. 966-71, doi:10.3329/bjp.v10i4.24165.

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Section

Research Articles