GC/MS analysis, antimicrobial and in vitro anti-cholinesterase activities of the essential oil from Buddleja asiatica

Authors

DOI:

https://doi.org/10.3329/bjp.v10i4.23991

Keywords:

Anti-cholinesterase, Antimicrobial, Buddleja asiatica, GC/MS

Abstract

Buddleja asiatica essential oil from the leaves by hydrodistillation was subjected to gas chromatography/mass spectrometery analysis which revealed the presence of 17 constituents out of which 14 were identified as: four monoterpenes hydrocarbons, four oxygenated monoterpenes, one hydrocarbon sesquiterpenes and five oxygenated sesquiterpenes. The major constituent being found was 1,8-cineole (38.1%) while β-sinensal, 1, 10-seco-1-hydroxy-calamenen-10-one and α-phellandrene were found to be in 11.8%, 10.2% and 5.8%, respectively. The essential oil exhibited 66% strong antibacterial activity against Shigella boydii while in fungicidal assay, it revealed an outstanding 79% inhibition against Aspergillus flavus. The essential oil showed outstanding acetylcholinesterase (IC50 5.2 μM) and butyrylcholinesterase inhibitory effect (IC50 27.9 μM) as compared to standard drugs respectively.

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Author Biographies

Farman Ali Khan, Departmenty of Chemistry, Shaheed Benazir Bhutto University, Sheringal, Dir (Upper), KP

Asssiatnt Professor and

Additional Director ORIC (Office of research innivation and commercialization

Abdul Khaliq Jan, Departmenty of Chemistry, Shaheed Benazir Bhutto University, Sheringal, Dir (Upper), KP

Assisstant Professor

Nasir Mehmood Khan, Departmenty of Chemistry, Shaheed Benazir Bhutto University, Sheringal, Dir (Upper), KP

Assisstant Professor

Nayab Ali Khan, Department of Chemistry, University of Science and Technology, Bannu, KP

MPhil Research Scholar

Shahnaz Khan, Department of Chemistry, University of Science and Technology, Bannu, KP

PhD Research Scholar

Additional Files

Published

2015-11-03

How to Cite

Khan, F. A., A. K. Jan, N. M. Khan, N. A. Khan, and S. Khan. “GC/MS Analysis, Antimicrobial and in Vitro Anti-Cholinesterase Activities of the Essential Oil from Buddleja Asiatica”. Bangladesh Journal of Pharmacology, vol. 10, no. 4, Nov. 2015, pp. 891-5, doi:10.3329/bjp.v10i4.23991.

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Section

Research Articles