In vitro thrombolytic, anthelmintic, anti-oxidant and cytotoxic activity with phytochemical screening of methanolic extract of Xanthium indicum leaves

  • Antara Ghosh Department of Pharmacy, Noakhali Science and Technology University, Noakhali 3814
  • Sujan Banik Department of Pharmacy, Noakhali Science and Technology University, Noakhali 3814 http://orcid.org/0000-0001-9639-6836
  • Md. Ariful Islam Department of Pharmacy, Noakhali Science and Technology University, Noakhali 3814
Keywords: Anthelmintic, Anti-oxidant, Cytotoxic, Thrombolytic, Xanthium indicum

Abstract

Xanthium indicum is an important medicinal plant traditionally used in Bangladesh as a folkloric treatment. The current study was undertaken to evaluate thrombolytic, anthelmintic, anti-oxidant, cytotoxic properties with phytochemical screening of methanolic extract of X. indicum leaves. The analysis of phytochemical screening confirmed the existence of phytosetrols and diterpenes. In thrombolytic assay, a significant clot lysis was observed at four concentrations of plant extract compare to the positive control streptokinase (30,000 IU, 15,000 IU) and negative control normal saline. The extract revealed potent anthelmintic activity at different concentrations. In anti-oxidant activity evaluation by two potential experiments namely total phenolic content determination and free radical scavenging assay by 2, 2-diphenylpicrylhydrazyl (DPPH), the leaves extract possess good anti-oxidant property. In the brine shrimp lethality bioassay, the crude extract showed potent (LC50 1.3 ?g/mL) cytotoxic activity compare to the vincristine sulfate as a positive control (LC50 0.8 ?g/mL). 

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Author Biographies

Sujan Banik, Department of Pharmacy, Noakhali Science and Technology University, Noakhali 3814
Lecturer
Md. Ariful Islam, Department of Pharmacy, Noakhali Science and Technology University, Noakhali 3814
Lecturer

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Published
2015-10-21
How to Cite
Ghosh, A., S. Banik, and M. Islam. “In Vitro Thrombolytic, Anthelmintic, Anti-Oxidant and Cytotoxic Activity With Phytochemical Screening of Methanolic Extract of Xanthium Indicum Leaves”. Bangladesh Journal of Pharmacology, Vol. 10, no. 4, Oct. 2015, pp. 854-9, doi:10.3329/bjp.v10i4.23829.
Section
Research Articles