Cytotoxic, thrombolytic, membrane stabilizing and anti-oxidant activities of Hygrophila schulli

Authors

  • Md. Abu Sufian Phytochemical Research Laboratory, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh
  • Mohammad Rashedul Haque Department of Pharmaceutical ChemistryFaculty of PharmacyUniversity of Dhaka, Dhaka 1000, Bangladesh http://orcid.org/0000-0001-5980-3877

DOI:

https://doi.org/10.3329/bjp.v10i3.23718

Keywords:

Antioxidant, Cytotoxic, Membrane stabilizing, Thrombolytic

Abstract

The crude methanol extract of Hygrophila schulli and its petroleum ether, chloroform, ethyl acetate and aqueous soluble Kupchan partitionates were investigated for in vitro cytotoxic, thrombolytic, membrane stabilizing and anti-oxidant activities. In the brine shrimp lethality bioassay, the petroleum ether soluble extract of H. schulli showed significant cytotoxicity (LC50 = 0.1 µg/mL and LC90 = 15 µg/mL) as compared to vincristine sulfate (LC50 = 0.4 µg/mL and LC90 = 9 µg/mL). Among all the partitionates, chloroform soluble fraction demonstrated the highest thrombolytic activity with 10.5% clot lyses. Moreover, in hypotonic- and heat-induced conditions, the chloroform soluble extractive inhibited hemolysis of human erythrocyte by 113.7% and 14.3%, respectively as compared to 71.9% and 42.2% demonstrated by standard acetylsalicylic acid. On the other hand, in anti-oxidant activity test, chloroform soluble fraction revealed mild antioxidant activity (IC50 = 195.1 µg/mL) as compared to standard tert-butyl-1-hydroxytoluene (IC50 = 27.5 µg/mL).

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Author Biography

Mohammad Rashedul Haque, Department of Pharmaceutical ChemistryFaculty of PharmacyUniversity of Dhaka, Dhaka 1000, Bangladesh

Associate Professor

Additional Files

Published

2015-08-13

How to Cite

Sufian, M. A., and M. R. Haque. “Cytotoxic, Thrombolytic, Membrane Stabilizing and Anti-Oxidant Activities of Hygrophila Schulli”. Bangladesh Journal of Pharmacology, vol. 10, no. 3, Aug. 2015, pp. 692-6, doi:10.3329/bjp.v10i3.23718.

Issue

Section

Research Articles