Sulphureuine B, a drimane type sesquiterpenoid isolated from Laetiporus sulphureus induces apoptosis in glioma cells

Authors

  • Jing-Wei Zhang Department of Medical Oncology, Nan Yang City Center Hospital, Henan 437009, China
  • Gong-Ling Wen Department of Medical Neurology, Nan Yang City Center Hospital, Henan 437009, China
  • Lei Zhang Department of Medical Oncology, Nan Yang City Center Hospital, Henan 437009, China
  • Dong-Mei Duan Department of Medical Oncology, Nan Yang Medical College, Henan 473000, China
  • Zhong-Hai Ren Department of Oncology, Nan Yang City Center Hospital, Henan 437009, China http://orcid.org/0000-0002-7052-5457

DOI:

https://doi.org/10.3329/bjp.v10i4.23708

Keywords:

Apoptosis, Glioma cell, Laetiporus sulphureus, Sulphureuine B

Abstract

A drimane type sesquiterpenoids, sulphureuine B was isolated from the edible mushroom Laetiporus sulphureus and its antiproliferative properties were investigated using U-87MG glioma cells. It was observed that sulphu-reuine B-induced apoptosis in U-87MG cells and the mechanisms involved are endoplasmic reticulum stress, mitochondrial and death receptor mediated pathways. Endoplasmic reticulum stress was identified from the results of enormous cytoplasmic vacuolation, CHOP elevation and caspase-12 cleavage. Further, we found that treatment of sulphureuine B-induced PERK, IRE1?, and ATF6? activations. In addition, sulphureuine B-induced Bcl-2 down-regulation, cleavage of PARP, and caspase-8 activation were also affected. All these experimental results clearly revealed that sulphureuine B-induced apoptosis mediated through endoplasmic reticulum stress, mitochondrial, and death receptor signaling pathways.

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Published

2015-10-21

How to Cite

Zhang, J.-W., G.-L. Wen, L. Zhang, D.-M. Duan, and Z.-H. Ren. “Sulphureuine B, a Drimane Type Sesquiterpenoid Isolated from Laetiporus Sulphureus Induces Apoptosis in Glioma Cells”. Bangladesh Journal of Pharmacology, vol. 10, no. 4, Oct. 2015, pp. 844-53, doi:10.3329/bjp.v10i4.23708.

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Section

Research Articles