Synthesis and biological evaluation of 6H-1-benzopyrano[4,3-b]quinolin-6-one derivatives as inhibitors of colon cancer cell growth

  • Tie-Ling Li Department of Pathology, MuDanJiang Medical University, Mudanjiang 157011
  • Hai-Feng Guo Department of General Surgery, The affiliated Red Hospital of Mudanjiang Medical University, Mudanjiang 157011 http://orcid.org/0000-0002-9628-9982
  • Fu-Juan Li Department of Pathogenic Biology and Immunology Laboratory?MuDanJiang Medical University, Mudanjiang 157011
  • Zhi-Guo Sun Department of General Surgery, The affiliated Red Hospital of Mudanjiang Medical University, Mudanjiang 157011
  • Heng-Chun Zhang Department of General Surgery, The affiliated Red Hospital of Mudanjiang Medical University, Mudanjiang 157011
Keywords: Cancer cell, Colon

Abstract

A convenient synthesis of 6H-1-benzopyrano[4,3-b]quinolin-6-one derivatives was reported using 4-chloro-2-oxo-2H-chromene-3-carbaldehyde with different aromatic amines using silica sulfuric acid. The compounds were tested for their anticancer activity against colon (HCT-116 and S1-MI-80), prostate (PC3 and DU-145), breast (MCF-7 and MDAMB-231) cancer cells. These com-pounds showed more selectivity and potent cytotoxic activity against colon cancer cells. 3c was tested against five other colon cancer cell lines (HT-29, HCT-15, LS-180, LS-174, and LoVo), which had similar cytotoxicity and selectivity. 3c did not induce PXR-regulated ABCB1 or ABCG2 transporters. In fact, 3c induced cytotoxicity in HEK293 cells over expressing ABCB1 or ABCG2 to the same extent as in normal HEK293 cells. It was cytotoxic approximately 3- and 5-fold to resistant colon carcinoma S1-MI-80 cells. 3c also produced concentration-dependent changes in HCT-116 colon cancer cells, in mitochondrial membrane potential, leading to apoptosis, and sub-micromolar concentrations caused chromosomal DNA fragmentation. 

 

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Published
2015-08-01
How to Cite
Li, T.-L., H.-F. Guo, F.-J. Li, Z.-G. Sun, and H.-C. Zhang. “Synthesis and Biological Evaluation Of 6H-1-Benzopyrano[4,3-B]quinolin-6-One Derivatives as Inhibitors of Colon Cancer cell Growth”. Bangladesh Journal of Pharmacology, Vol. 10, no. 3, Aug. 2015, pp. 660-71, doi:10.3329/bjp.v10i3.23645.
Section
Research Articles