Phytochemical characterization of phenolics by LC-MS/MS and biological evaluation of Ajuga orientalis from Turkey

Authors

  • Fatih Göger Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, Eskisehir 26470, Turkey
  • Yavuz Bülent Köse Department of Pharmacutical Botany, Faculty of Pharmacy, Anadolu University, Eskisehir 26470, Turkey http://orcid.org/0000-0002-3060-7271
  • Gamze Göger Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, Eskisehir 26470, Turkey
  • Fatih Demirci Faculty of Health Sciences, Anadolu University, Eskisehir 26470, Turkey

DOI:

https://doi.org/10.3329/bjp.v10i3.23500

Keywords:

Ajuga orientalis, Antioxidant, Antimicrobial activities, LC-MS/MS analysis

Abstract

The aim of this study was to reveal the phytochemical constituents, antioxidant and antimicrobial activity of Ajuga orientalis. According to the antimicrobial results, the methanol extract of A. orientalis showed a MIC value of 312.5 µg/mL against the tested pathogenic bacterial strains. Anticandidal activity of extract was found as 156.3 µg/mL both against Candida albicans and C. parapsilosis strains. Whereas the extract was more effective against C. tropicalis with the MIC value of 78.1 µg/mL. The in vitro DPPH radical scavenging activity of the extract was determined as IC50=0.4 ± 0.02 mg/mL whereas the standard BHT IC50 was 0.01 ± 0.00 mg/mL. Trolox Equivalent Antioxidant Capacity (TEAC) of extract was determined 1.3 mM TEAC, while BHT, 1.9 mM TEAC.

 

Downloads

Download data is not yet available.
Abstract
3635
Download
2953 Read
1564

Author Biography

Yavuz Bülent Köse, Department of Pharmacutical Botany, Faculty of Pharmacy, Anadolu University, Eskisehir 26470, Turkey

Associate Professor

Downloads

Additional Files

Published

2015-07-15

How to Cite

Göger, F., Y. B. Köse, G. Göger, and F. Demirci. “Phytochemical Characterization of Phenolics by LC-MS/MS and Biological Evaluation of Ajuga Orientalis from Turkey”. Bangladesh Journal of Pharmacology, vol. 10, no. 3, July 2015, pp. 639-44, doi:10.3329/bjp.v10i3.23500.

Issue

Vol. 10 No. 3 (2015)

Section

Research Articles

License

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).