Effects of paeonol on the expression of NF-κB pathways in human umbilical veins endothelial cells induced by homocysteine

Authors

  • Qian Xu School of Chengde Medical College, Chengde 067000, Hebei, China
  • Kai Cao Department of Biochemistry, School of Chengde Medical College, Chengde 067000, Hebei, China
  • Yan-Hong Xiao Department of Biochemistry, School of Chengde Medical College, Chengde 067000, Hebei, China
  • Chao Du School of Chengde Medical College, Chengde 067000, Hebei, China
  • Xian-Hui Dong Department of Anatomy, School of Chengde Medical College, Chengde 067000, Hebei, China
  • Yu Wang School of Chengde Medical College, Chengde 067000, Hebei, China
  • Xiao-Hui Zhou Department of Biochemistry, School of Chengde Medical College, Chengde 067000, Hebei, China

DOI:

https://doi.org/10.3329/bjp.v10i3.23414

Keywords:

Homocysteine, Human umbilical veins endothelial cell, NF-?B pathway, Paeonol

Abstract

The aim of this study was to investigate the effects of paeonol on the expression of NF-κB pathway induced by homocysteine. After Human umbilical vein endothelial cells exposed to homocysteine for 24 hours,  paeonol (0.15-0.6 mmol/L) improved the cell viability (p<0.05). NF-κB p65 mRNA expression was reduced largely (p<0.05) and IκB-α protein expression increased significantly (p<0.01). The staining of NF-κB p65 in nucleus was not as much as those in homocysteine injured model group (p<0.01). Therefore, paeonol can inhibit IκB-α protein degradation and suppress NF-κB transferred into nuclear in order to inhibit the activation of NF-κB.

 

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Published

2015-07-10

How to Cite

Xu, Q., K. Cao, Y.-H. Xiao, C. Du, X.-H. Dong, Y. Wang, and X.-H. Zhou. “Effects of Paeonol on the Expression of NF-κB Pathways in Human Umbilical Veins Endothelial Cells Induced by Homocysteine”. Bangladesh Journal of Pharmacology, vol. 10, no. 3, July 2015, pp. 604-11, doi:10.3329/bjp.v10i3.23414.

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Section

Research Articles