Anti-oxidant, hypoglycemic and anti-hyperglycemic properties of Syzygium calophyllifolium

Authors

  • Rahul Chandran Bioprospecting Laboratory, Department of Botany, Bharathiar University, Coimbatore, Tamil Nadu, India
  • Saikumar Sathyanarayanan Bioprospecting Laboratory, Department of Botany, Bharathiar University, Coimbatore, Tamil Nadu, India
  • Murugan Rajan Bioprospecting Laboratory, Department of Botany, Bharathiar University, Coimbatore, Tamil Nadu, India
  • Muniyandi Kasipandi Bioprospecting Laboratory, Department of Botany, Bharathiar University, Coimbatore, Tamil Nadu, India
  • Thangaraj Parimelazhagan Bioprospecting Laboratory, Department of Botany, Bharathiar University, Coimbatore, Tamil Nadu, India

DOI:

https://doi.org/10.3329/bjp.v10i3.23361

Keywords:

Free radicals, Glucose tolerance, Hyperglycemia, Phenolic, Syzygium calophyllifolium

Abstract

The article discusses anti-oxidant oral glucose tolerance and anti-hyperglycemic potentials of Syzygium calophyllifolium. Extracts from successive solvent extraction were tested for the total phenolic, tannin, flavonoid content and free radical scavenging property using DPPH, ABTS+, phosphomolyb-denum, FRAP, superoxide and metal chelating assays. Ethyl acetate extract of bark responded well against DPPH (IC50 4.13), ABTS+ (36832.29 µM TE/ g extract),phosphomolybdenum (100.4 g AAE/100g extract), superoxide and metal ion radicals. The methanol extract of bark was also found as an effective radical scavenger. The leaf methanol extract also showed significant anti-oxidant ability. The bark methanol extract could potentially reduce the blood glucose level in glucose loaded and diabetic rats. The immense anti-oxidant potential of S. calophyllifolium leaf and bark extracts could be taken as a good source of natural anti-oxidant supplement in food to defend oxidative stress related disorders like diabetes.

 

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Author Biographies

Rahul Chandran, Bioprospecting Laboratory, Department of Botany, Bharathiar University, Coimbatore, Tamil Nadu, India

Ph.D Scholar

Saikumar Sathyanarayanan, Bioprospecting Laboratory, Department of Botany, Bharathiar University, Coimbatore, Tamil Nadu, India

M.Phil Scholar

Murugan Rajan, Bioprospecting Laboratory, Department of Botany, Bharathiar University, Coimbatore, Tamil Nadu, India

Ph.D Scholar

Muniyandi Kasipandi, Bioprospecting Laboratory, Department of Botany, Bharathiar University, Coimbatore, Tamil Nadu, India

M.Phil Scholar

Thangaraj Parimelazhagan, Bioprospecting Laboratory, Department of Botany, Bharathiar University, Coimbatore, Tamil Nadu, India

Associate Professor

Published

2015-08-03

How to Cite

Chandran, R., S. Sathyanarayanan, M. Rajan, M. Kasipandi, and T. Parimelazhagan. “Anti-Oxidant, Hypoglycemic and Anti-Hyperglycemic Properties of Syzygium Calophyllifolium”. Bangladesh Journal of Pharmacology, vol. 10, no. 3, Aug. 2015, pp. 672-80, doi:10.3329/bjp.v10i3.23361.

Issue

Section

Research Articles