Anti-diabetic activity of crude Pistacia lentiscus in alloxan-induced diabetes in rats

  • Muhammad Saad Ur Rehman University College of Pharmacy,University of the Punjab, Lahore, Pakistan
  • Sairah Hafeez Kamran University College of Pharmacy,University of the Punjab, Lahore, Pakistan
  • Mobasher Ahmad University College of Pharmacy,University of the Punjab, Lahore, Pakistan
  • Usman Akhtar University College of Pharmacy,University of the Punjab, Lahore, Pakistan
Keywords: Diabtes mellitus, Mastic gum, Pistacia lentiscus


The purpose of this study was to investigate the anti-diabetic effect of crude Pistacia lentiscus gum (mastic gum) in alloxan-treated diabetic rat model. The crude P. lentiscus (100 mg/kg) showed significant (p<0.001) reduction in blood glucose as compared to control. Liver function test also showed significant changes (p<0.001) as compared to alloxan-treated group. The results of this study showed that crude P. lentiscus gum have considerable efficacy in curing diabetes and have hepatoprotective effect.   



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Aksoy A, Duran N, Koksal F. In vitro and in vivo antimicrobial effects of mastic chewing gum against Streptococcus mutans and mutans streptococci. Arch Oral Biol. 2006; 51: 476-81.

Baldé NM, Youla A, Balde MD, Kake A, Diallo MM, Baldé MA, Maugendre D. Herbal medicine and treatment of diabetes in Africa: An example from Guinea. Diabetes Metab J. 2006; 32: 171-75.

Hosseinzadeh H, Sajadi Tabassi SA, Milani Moghadam N, Rashedinia M, Mehri S. Antioxidant activity of Pistacia vera fruits, leaves and gum extracts. Iran J Pharm Res. 2012; 11: 879-87.

Huwez FU, Thirlwell D, Cockayne A, Ala'Aldeen DAA. Mastic gum kills Helicobacter pylori. New Engl J Med. 1998; 339: 1946-46.

Koutsoudaki C, Krsek M, Rodger A. Chemical composition and antibacterial activity of the essential oil and the gum of Pistacia lentiscus Var. chia. J Agric Food Chem. 2005; 53: 7681-85.

Ku G, Kegels G. The performance of the Finnish diabetes risk score: A modified Finnish diabetes risk score and a simplified Finnish diabetes risk score in community-based cross-sectional screening of undiagnosed type 2 diabetes in the Philippines. Prim Care Diabetes. 2013; 7: 249-59.

Larcan A, Lambert H, Laprevote-Heully MC, Delorme N. [Light and electron microscopic study of hepatic lesions in the course of hyperlactatemia in diabetic patients (author's transl)]. Diabete Metabolisme. 1979; 5: 103-12.

Concepción Navarro M, Pilar Montilla M, Martín A, Jiménez J, Pilar Utrilla M. Free radical scavenger and antihepatotoxic activity of Rosmarinus tomentosus. Planta Medica. 1993; 59: 312-14.

Paraschos S, Magiatis P, Mitakou S, Petraki K, Kalliaropoulos A, Maragkoudakis P, Mentis A, Sgouras D, Skaltsounis AL. In vitro and in vivo activities of Chios mastic gum extracts and constituents against Helicobacter pylori. Antimicrob Agents Chemother. 2007; 51: 551-59.

Rao BK, Rao CH. Hypoglycemic and antihyperglycemic activity of Syzygium alternifolium (Wt.) Walp. seed extracts in normal and diabetic rats. Phytomedicine 2001; 8: 88-93.

Sakurai K, Katoh M, Someno K, Fujimoto Y. Apoptosis and mitochondrial damage in INS-1 cells treated with alloxan. Biol Pharm Bull. 2001; 24: 876-82.

Sushruta K, Satyanarayana S, Srinivas S, Sekhar JR. Evaluation of the blood-glucose reducing effects of aqueous extracts of the selected umbelliferous fruits used in culinary practices. Tropical J Pharm Res. 2007; 5: 613-17.

Takahashi K, Fukazawa M, Motohira H, Ochiai K, Nishikawa H, Miyata T. A pilot study on antiplaque effects of mastic chewing gum in the oral cavity. J Periodontol. 2003; 74: 501-05.

Triantafyllou A, Chaviaras N, Sergentanis TN, Protopapa E, Tsaknis J. Chios mastic gum modulates serum biochemical parameters in a human population. J Ethnopharmacol. 2007; 111: 43-49.

How to Cite
Saad Ur Rehman, M., S. Hafeez Kamran, M. Ahmad, and U. Akhtar. “Anti-Diabetic Activity of Crude Pistacia Lentiscus In alloxan-Induced Diabetes in Rats”. Bangladesh Journal of Pharmacology, Vol. 10, no. 3, July 2015, pp. 543-7, doi:10.3329/bjp.v10i3.23225.
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