Antiviral mode of action of Lactobacillus plantarum YML009 on Influenza virus H1N1

Authors

DOI:

https://doi.org/10.3329/bjp.v10i2.23068

Keywords:

H1N1, Influenza virus, Lactic acid bacteria, Probiotic

Abstract

The development of resistance against antiviral agents has augmented a threat to public health sector. Consequently there is an expanding demand for the development of unconventional antiviral agents that could efficiently replace the existent in-use drugs. The probiotic strains of lactic acid bacteria (LAB) have earned the status of being efficient, economical and safe 'nutraceutical' in health care armamentarium. A total of 2272 LAB strains were screened against H1N1 virus. The isolate YML009 displayed a pronounced antiviral activity. Sequencing and biochemical assays identified the isolate as Lactoballius plantarum which, exhibited resistance to the damage caused by the acidic conditions such as gastric juice and 5% bile salt. The anti-H1N1 activity of the strain was confirmed by hemagglutination assay and was found to display enhanced efficacy in comparison to the commercially available antiviral drug. This is a primary report on anti-influenza activity of a bacterium L. plantarum YML009.  

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Author Biographies

Irfan Ahmad Rather, Department of Applied Microbiology and Biotechnology, School of Biotechnology, Yeungnam UniversityGyeongsan si, Gyeongsan

Assistant Professor 

Kwang-Ho Choi, Department of Applied Microbiology and Biotechnology, School of Biotechnology, Yeungnam UniversityGyeongsan si, Gyeongsan

Graduate Student 

 

Vivek K. Bajpai, Department of Applied Microbiology and Biotechnology, School of Biotechnology, Yeungnam UniversityGyeongsan si, Gyeongsan

Professor

 

Yong-Ha Park, Department of Applied Microbiology and Biotechnology, School of Biotechnology, Yeungnam UniversityGyeongsan si, Gyeongsan

Professor

 

Additional Files

Published

2015-06-01

How to Cite

Rather, I. A., K.-H. Choi, V. K. Bajpai, and Y.-H. Park. “Antiviral Mode of Action of Lactobacillus Plantarum YML009 on Influenza Virus H1N1”. Bangladesh Journal of Pharmacology, vol. 10, no. 2, June 2015, pp. 475-82, doi:10.3329/bjp.v10i2.23068.

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Section

Research Articles