Phytochemical screening and diuretic activity of Euphorbia granulata
DOI:
https://doi.org/10.3329/bjp.v10i3.22844Keywords:
Diuretic, Euphorbia granulataAbstract
The aim of this study was to evaluate diuretic activity of aqueous methanolic extract of Euphorbia granulate in rats. Albino rats were divided into five groups. Group I served as reference, Group II as standard and Group III, IV and V served as test. The three doses of extract (30, 50 and 100 mg/kg) were given to rats (i.p) in acute diuretic model. Furosemide (10 mg/kg i.p) was used as standard drug. The extract induced diuretic effects and induced electrolytes excretion in a dose-dependent manner when compared with control. The extract (100 and 50 mg/kg) significantly (p<0.01) increased the volume of urine in comparison to control group. Similarly, the excretion of potassium and sodium were also significantly (p<0.05) increased following extract administration. However, there was no significant change in the pH of urine samples of the extract-treated group compared with control. The result of this study thus offers support to the traditional folker use of this plant as a diuretic agent.
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