Hepatoprotective effects of Sapium sebiferum in paracetamol-induced liver injury

  • Liaqat Hussain Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Faisalabad, Pakistan
  • Muhammad Sajid Hamid Akash Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Faisalabad, Pakistan
  • Madeha Tahir Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Faisalabad, Pakistan.
  • Kanwal Rehman Institute of Pharmacy, Physiology and Pharmacology, University of Agriculture, Faisalabad, Pakistan.
Keywords: Hepatotoxicity, Paracetamol, Sapium sebiferum, Silymarin

Abstract

Sapium sebiferum leaves were used to determine its hepatoprotective effects against paracetamol-induced hepatotoxicity in mice. A dose dependent study was conducted using two different doses (200 mg/kg and 400 mg/kg) of the extract of S. sebiferum against toxic effects of paracetamol (500 mg/kg) in experimental animal model. Silymarin (50 mg/kg) was used as standard drug to compare therapeutic effects of S. sebiferum with control and paracetamol-treated groups. Paracetamol significantly increased the serum levels of liver enzyme markers like alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, total bilirubin, and direct bilirubin. The extract showed protective effects by normalizing the liver enzymes markers in a dose dependent manner. Histopathological results confirmed the hepatoprotective effects of leaves of S. sebiferum. We conclude that leaves of S. sebiferum have strong hepatoprotective effects against paracetamol-induced liver injury and can be used in liver injuries caused by drug-induced toxicity.

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Published
2015-05-02
How to Cite
Hussain, L., M. Akash, M. Tahir, and K. Rehman. “Hepatoprotective Effects of Sapium Sebiferum in Paracetamol-Induced Liver Injury”. Bangladesh Journal of Pharmacology, Vol. 10, no. 2, May 2015, pp. 393-8, doi:10.3329/bjp.v10i2.22576.
Section
Research Articles

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