Kaempferol modulates the metastasis of human non-small cell lung cancer cells by inhibiting epithelial-mesenchymal transition

Meng Hang, Fan Zhao, Shu-Bo Chen, Qing Sun, Chun-Xiao Zhang

Abstract

The present study was done to determine whether kaempferol, a natural polyphenol of the flavonoid family, affects Epithelial-Mesenchymal Transition (EMT) in non-small cell lung cancer cells. Kaempferol not only inhibited cancer cell proliferation and migration in a dose-dependent manner but also modulated the expression of EMT-related proteins E-cadherin and vimentin which are indispensible to cellular motility, invasiveness and metastasis. These results indicate that kaempferol suppresses non-small cell lung cancer migration by modulating the expression of EMT proteins. Therefore, kaempferol may be useful as a potential anticancer agent for non-small cell lung cancer.

Keywords

Epithelial-Mesenchymal Transition; Kaempferol; Non-small cell lung cancer

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DOI: http://dx.doi.org/10.3329/bjp.v10i2.21739

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Copyright (c) 2015 Meng Hang, Fan Zhao, Shu-Bo Chen, Qing Sun, Chun-Xiao Zhang

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Bangladesh Journal of Pharmacology (Bangladesh J Pharmacol) is a single-blinded peer-reviewed, video component, open access official publication of the Bangladesh Pharmacological Society (BDPS). eISSN: 1991-0088. For contact: Editor-In-Chief