Kaempferol modulates the metastasis of human non-small cell lung cancer cells by inhibiting epithelial-mesenchymal transition

  • Meng Hang Department of Oncology, Jiangsu Province Wuxi No. 2 People's Hospital, Wuxi 214002, China
  • Fan Zhao Department of Oncology, Jiangsu Province Wuxi No. 2 People's Hospital, Wuxi 214002, China
  • Shu-Bo Chen Department of Oncology, Jiangsu Province Wuxi No. 2 People's Hospital, Wuxi 214002, China
  • Qing Sun Department of Oncology, Jiangsu Province Wuxi No. 2 People's Hospital, Wuxi 214002, China
  • Chun-Xiao Zhang Department of Oncology, Jiangsu Province Wuxi No. 2 People's Hospital, Wuxi 214002, China
DOI: https://doi.org/10.3329/bjp.v10i2.21739
Keywords: Epithelial-Mesenchymal Transition, Kaempferol, Non-small cell lung cancer

Abstract

The present study was done to determine whether kaempferol, a natural polyphenol of the flavonoid family, affects Epithelial-Mesenchymal Transition (EMT) in non-small cell lung cancer cells. Kaempferol not only inhibited cancer cell proliferation and migration in a dose-dependent manner but also modulated the expression of EMT-related proteins E-cadherin and vimentin which are indispensible to cellular motility, invasiveness and metastasis. These results indicate that kaempferol suppresses non-small cell lung cancer migration by modulating the expression of EMT proteins. Therefore, kaempferol may be useful as a potential anticancer agent for non-small cell lung cancer.

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Published
2015-04-01
How to Cite
Hang, M., F. Zhao, S.-B. Chen, Q. Sun, and C.-X. Zhang. “Kaempferol Modulates the Metastasis of Human Non-Small Cell Lung Cancer Cells by Inhibiting Epithelial-Mesenchymal Transition”. Bangladesh Journal of Pharmacology, Vol. 10, no. 2, Apr. 2015, pp. 267-70, doi:10.3329/bjp.v10i2.21739.
Issue
Vol 10 No 2 (2015)
Section
Research Articles

Copyright (c) 2015 Meng Hang, Fan Zhao, Shu-Bo Chen, Qing Sun, Chun-Xiao Zhang

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