Cardioprotective activity of fruits of Sechium edule

  • Kosanam Neeraja Department of Pharmacology, Calcutta Institute of Pharmaceutical Technology & AHS, Uluberia, Howrah 711316, West Bengal
  • Rabindra Debnath Department of Pharmacology, Calcutta Institute of Pharmaceutical Technology & AHS, Uluberia, Howrah 711316, West Bengal
  • S. M. Firdous Department of Pharmacology, Calcutta Institute of Pharmaceutical Technology & AHS, Uluberia, Howrah 711316, West Bengal
Keywords: Cardioprotective, Isoproterenol, Sechium edule

Abstract

The present work deals with the study of the ethanolic extract of fruits of Sechium edule for cardioprotective activity. Cardioprotective activity of the ethanolic extract of fruits of Sechium edule was determined by the administration of isoproterenol (60 mg/kg, s.c) for two days. Pretreatment with Sechium edule (200 mg/kg, p.o and 100 mg/kg, p.o) for 28 days in significantly (P<0.01) reduce the levels of serum SGOT, SGPT, ALP, LDH, CK, Total Cholesterol, triglycerides, LDL-C, VLDL-C and increase the levels of HDL-C. Histopathological studies of the hearts of ISO treated rats have showed infiltration of inflammatory cells and continuity in muscle fiber was lacking suggesting an irreversible cell injury. Animals treated with ethanolic extract of Sechium edule showed less degenerative changes compared to ISO - treated animals.

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References

Albone KS, Gaskin P, MacMillan J, Sponsel VM. Identification and localization of gibberlins in maturing seed of cucurbit Sechium edule, and a comparison between this cucurbit and the legume Phaseolus coccineus. Planta Springer-verla. 1984; 162: 560-65.

Farvin KH, Anandan R, Kumar SH, Shiny KS, Mathew S, Sankar TV, Nair PG. Cardioprotective effect of Squalene on lipid profile in isoprenaline-induced myocardial infarction in rats. J Med Food. 2006; 9: 531-36.

Firdous SM, Sravanthi K, Debnath R, Neraja K. Protective effect of ethanolic extract and its ethylacetate and n-butanol fractions of Sechium edule fruits against carbon tetrachloride induced hepatic injury in rats. Int J Pharm Pharm Sci. 2012; 4: 354-59.

Firdous SM, Neraja K, Debnath R, Singha D, Sravanthi K. Evaluation of antiulcer activity of ethanolic extract of Sechium edule fruits in experimental rats. Int J Pharm Pharm Sci. 2012; 4: 374-77.

Gordon EA, Guppy LJ, Nelson M. The antihypertensive effects of the Jamaican Cho-Cho (Sechium edule). West Ind Med J. 2000; 49: 27-31.

Harborne JB. Textbook of phytochemical methods. 1st ed. London, Champraan and Hall Ltd., 1973, pp 110-13.

Kamble MB, Dumbre RK, Rangari VD. Hepatoprotective activity studies of herbal formulations. Int J Green Pharm. 2008; 2: 147-51.

Kareem MA, Krushna GS, Hussain SA, Dev, KL. Effect of aqueous extract of nutmeg on hyperglycaemia, hyperlipidaemia and cardiac histology associated with isoproterenol-induced myocardial infarction in rats. Trop J Pharmaceutical Res. 2009; 8: 337-44.

Koneri R, Balaraman R, Hariprasad, Vinoth Kumar M, Ali A. Cardioprotective effect of Momordica cymbalaria fenzl in rats with isoproterenol induced myocardial injury. J Clin Diag Res. 2008; 2: 699-705.

Lopez AD, Murray CJL. The global burden disease 2000 project: Aims, methods and data sources. Nat Med. 2000; 4: 123-24.

Maity S, Firdous SM, Debnath R. Evaluation of antidiabetic activity of ethanolic extract of Sechium edule fruits in alloxan-induced diabetic rats. World J Pharm Pharm Sci. 2013; 2: 3612-21.

OECD, 2002. Acute oral toxicity. Acute oral toxic class method guideline 423 adopted 23.03.1996. In: Eleventh addendum to the, OECD, guidelines for the testing of chemicals organisation for economics co-operation, development, Paris, 2000.

Ordonez AA, Gomez JD, Isla MA. Antioxidant activities of Sechium edule (Jacq.) Swartz extracts. Food Chem. 2006; 97: 452-58.

Sabeena Farvin KH, Anandan R, Hari Senthil KS, Shiny KS. Cardioprotective effect of squalene on lipid profile in isoprenaline-induced myocardial infarction in rats. J Med Food. 2006; 9: 531-36.

Sayeed MFM, Ahmed S, Dey S. Antiepileptic and central nervous system depressant activity of Sechium edule fruit extract. Bangladesh J Pharmacol. 2012; 7: 199-202.

Sayeed MFM, Paul S, Bag AK. Effect of Sechium edule on chemical induced kidney damage in experimental animals. Bangladesh J Pharmacol. 2013; 8: 28-35.

Siciliano T, De Tommasi N. Study of flavonoids of Sechium edule (Jacq) swartz (Cucurbitaceae) different edible organs by liquid chromatography photodiode array mass spectrometry. J Agric Food Chem. 2004; 52: 65105.

Thippeswamy BS, Thakker SP, Tubachi S, Kalyani GA, Netra MK, Patil U, Desai S, Gavimath CC, Veerapur VP. Cardioprotective effect of Cucumis trigonus roxb on isoproterenol-induced myocardial infarction in rat. Am J Pharmacol Toxicol. 2009; 4: 29-37.

Vandana SP, Suresh R. Evaluation of cardioprotective activity of Ginkgo biloba and Ocimum sanctum in rodents. Altr Med Rev. 2009; 14: 161-71.

Vijaypadma V, Shyamaladevi CS. Effect of fish oil on isoproterenol induced myocardial necrosis isoproterenol-induced lesions in the rat. Indian J Pharmacol. 2000; 32: 324-26.

Vozari-Hampe MM, Viegas C, Saucedo C, Rosseto S, Manica GG, Hampe OG. A lectin from Sechium edule fruit exudates. Phytochemistry 1992; 31: 1477-80.

Published
2015-02-18
How to Cite
Neeraja, K., R. Debnath, and S. M. Firdous. “Cardioprotective Activity of Fruits of Sechium Edule”. Bangladesh Journal of Pharmacology, Vol. 10, no. 1, Feb. 2015, pp. 125-30, doi:10.3329/bjp.v10i1.21329.
Section
Research Articles