Effects of fisetin on oxaliplatin-induced neuropathic pain in mice

  • Hong Liu School of Medicine, Hubei University for Nationalities, Enshi, Hubei, 445000
  • Chaohua Wang Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu
  • Hua Yang Departments of Neurology and Pneumology, University Hospital of Hubei University for Nationalities, Enshi, Hubei 445000
  • Fengjie Wang School of Medicine, Hubei University for Nationalities, Enshi, Hubei, 445000
Keywords: Fisetin, Mice, Neuropathic pain, Oxaliplatin

Abstract

Common chemotherapeutic agents such as oxaliplatin often cause neuropathic pain during cancer treatment in patients. Such neuropathic pain is difficult to treat and responds poorly to common analgesics, which represents a challenging clinical issue. Fisetin is a naturally occurring flavonoid and this study tested the potential anti-hyperalgesic effects of fisetin in a mice model of oxaliplatin-induced neuropathic pain. Fisetin (1-4 mg/kg, i.p.) did not significantly alter the mechanical hypersensitivity in oxaliplatin-treated mice but produced a dose-dependent anti-hyperalgesic effect during repeated treatment. Repeated treatment with fisetin also prevented chronic neuropathic pain-induced depressive-like behavior in a forced swimming test. Both the antihyperalgesic and the antidepressant-like effects of fisetin can be blocked by a selective 5-HT1A receptor antagonist WAY100635 (1 mg/kg). Together, these results demonstrate that fisetin has significant analgesic efficacy against chronic neuropathic pain, which could be a useful analgesic in the management of neuropathic pain.

Downloads

Download data is not yet available.
Abstract
845
Download
519 Read
450

References

Cheong H, Ryu SY, Oak MH, Cheon SH, Yoo GS, Kim KM. Studies of structure activity relationship of flavonoids for the anti-allergic actions. Arch Pharm Res. 21998; 1: 478-80.

Colpaert FC. 5-HT(1A) receptor activation: New molecular and neuroadaptive mechanisms of pain relief. Curr Opin Investig Drugs. 2006; 7: 40-47.

Dixon WJ. Efficient analysis of experimental observations. Annu Rev Pharmacol Toxicol. 1980; 20: 441-62.

Khan N, Syed DN, Ahmad N, Mukhtar H. Fisetin: A dietary antioxidant for health promotion. Antioxid Redox Signal. 2013; 19: 151-62.

Li JX. Pain and depression comorbidity: A preclinical perspective. Behav Brain Res. 2015; 276: 92-98.

Patel MY, Panchal HV, Ghribi O, Benzeroual KE. The neuroprotective effect of fisetin in the MPTP model of Parkinson's disease. J Parkinsons Dis. 2012; 2: 287-302.

Porsolt RD, Bertin A, Jalfre M. Behavioral despair in mice: A primary screening test for antidepressants. Arch Int Pharmacodyn Ther 1977; 229: 327-36.

Ravichandran N, Suresh G, Ramesh B, Siva GV. Fisetin, a novel flavonol attenuates benzo(a)pyrene-induced lung carcinogenesis in Swiss albino mice. Food Chem Toxicol. 2011; 49: 1141-47.

Published
2015-02-20
How to Cite
Liu, H., C. Wang, H. Yang, and F. Wang. “Effects of Fisetin on Oxaliplatin-Induced Neuropathic Pain in Mice”. Bangladesh Journal of Pharmacology, Vol. 10, no. 1, Feb. 2015, pp. 138-42, doi:10.3329/bjp.v10i1.21203.
Section
Research Articles