Analgesic and anti-inflammatory activities of leaf extract of Kydia calycina Roxb.

Baburao Bhukya, Rama Narsimha Reddy Anreddy, Carey M. William, Krishna Mohan Gottumukkala


The methanol extract of leaves of Kydia calycina Roxb. was screened for the analgesic (using hot plate test and acetic acid-induced writhing test in mice) and anti-inflammatory (using rat paw edema test) activity at the doses of 200 and 400 mg/kg body weight. A significant (p<0.0005) analgesic effect was observed with 200 mg/kg and 400 mg/kg in both tests. The maximum anti-inflammatory response was produced at 3 hour with extract doses of 200 and 400 mg/kg. These results suggest that the methanol extract of K. calycina hasexhibited significant analgesic and anti-inflammatory effects, which were comparable with standard drugs.


Analgesic; Anti-inflammatory; Carrageenan; Kydia calycina

Full Text:



Crunkhon P, Meacock SER. Mediators of the inflammation induced in the rat paw by carrageenan. Bri J Pharmacol. 1971; 42: 392-402.

Eddy NB, Leimback D. Synthetic analgesic. II. Dithienylbutenyl and dithienylbutylamines. J Pharmacol Exp Ther. 1953; 107: 385-93.

Just MJ, Recio MC, Giner RM, Cullar MJ, Manez S, Bilia AR. Anti-inflammatory activity of unusual lupine saponins from Bupleurum fruticescens. Planta Medica 1998; 64: 404-07.

Koster R, Anderson M, De-Beer EJ. Acetic acid analgesic screen. Federation Proc. 1959; 18: 418-20.

Ochi T, Motoyama Y, Goto T. The analgesic effect profile of FR122047, a selective cyclooxygenase-1 inhibitor, in chemical nociceptive models. Eur J Pharmacol. 2000; 391: 49–54.

Panthong A, Kanjanapothi D, Taesotikul T, Wongcome T, Reutrakul V. Anti-inflammatory and antipyretic properties of Clerodendrum petasites S. Moore. J Ethnopharmacol. 2003; 85:151-56.

Parrotta JA. Healing plants of peninsular India. New Delhi, CABI publishing, 2001, pp 480-81.

Trease EG, Evan WC. Textbook of pharmacognosy. 12th ed, Oxford, Alden Press, 1983, pp 343-83.

Vinegar R, Schreiber W, Hugo R. Biphasic development of carrageenan edema in rats. J Pharmacol Exp Ther. 1969; 166: 96-103.

Winter CA, Risley EA, Nuss GW. Carrageenan induced edema in hind paw of the rat as an assay for anti-inflammatory drugs. Proc. Soc. Exp. Biol. Med 1962; 111: 544-47.


Copyright (c) 2009 Baburao Bhukya, Rama Narsimha Reddy Anreddy, Carey M. William, Krishna Mohan Gottumukkala

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.