Anti-cancer potential of banana flower extract: An in vitro study

  • Varalakshmi Kilingar Nadumane Department of Biotechnology, Centre for Post-Graduate Studies, Jain University, Jayanagar, Bangalore 560 011
  • Bibechana Timsina Department of Biotechnology, Centre for Post-Graduate Studies, Jain University, Jayanagar, Bangalore 560 011
Keywords: Anti-cancer, antiproliferative, banana flower, bioactive fraction, cytotoxic, HeLa cells

Abstract

Banana (Musa paradisiaca) flower is rich in phytochemicals (vitamins, flavonoids, proteins) and has antioxidant properties. The anti-cancer activity of banana flower extract has been evaluated on the cervical cancer cell line HeLa. The antiproliferative effects were evaluated by MTT assay. The extract was further purified by TLC and characterized by LC-MS method. The ethanol extract had significant cytotoxicity to HeLa cells with an IC50 of 20 µg/mL. By thin layer chromatography we could isolate three fractions out of which fraction 2 had exhibited maximum anti-proliferative effects with an IC50 value of <10 µg/mL. By LC-MS analysis, bioactive fraction was found to have an m/z value of 224.2 indicating it as a novel one.

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Author Biography

Varalakshmi Kilingar Nadumane, Department of Biotechnology, Centre for Post-Graduate Studies, Jain University, Jayanagar, Bangalore 560 011

Associate Professor

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Published
2014-11-29
How to Cite
Nadumane, V., and B. Timsina. “Anti-Cancer Potential of Banana Flower Extract: An in Vitro Study”. Bangladesh Journal of Pharmacology, Vol. 9, no. 4, Nov. 2014, pp. 628-35, doi:10.3329/bjp.v9i4.20610.
Section
Research Articles