Design, docking, synthesis and anticancer activity of some novel 2-(4-methylbenzenesulphonamido)pentanedioic acid amide derivatives

  • Satyajit Dutta Department of Pharmaceutical Chemistry, IIMT College of Medical Sciences, Meerut 250001, Uttar Pradesh
  • Deepak Kumar Department of Pharmaceutical Chemistry, IIMT College of Medical Sciences, Meerut 250001, Uttar Pradesh
  • Anand Kumar Mishra Department of Pharmaceutical Chemistry, IIMT College of Medical Sciences, Meerut 250001, Uttar Pradesh
  • Supratim Ray Department of Pharmaceutical Sciences, Assam University, Silchar 788011, Assam
  • K. Nagarajan Department of Pharmaceutical Chemistry, KIET School of Pharmacy, Muradnagar, Ghaziabad 201206, Uttar Pradesh
Keywords: Glutamic acid (2-amino pentanedioic acid), Docking, Anticancer, Ehrlich ascites carcinoma.

Abstract

In the present work few novel 2-(4-methylbenzenesulphonamido)pentanedioic acid amide derivatives and the basic compound 2-(4-methylphenylsulfon-amido)pentanedioic acid have been designed, synthesized, characterized and screened for their possible antineoplastic activity both in vitro and in vivo. The modified drugs were docked against the protein histone deacetylase the energy value obtained was o-iodoanilide (-10.370504) and m-iodoanilide (-10.218276) of the titled compound. The in vitro activity was performed against five human cell lines like human breast cancer (MCF-7), leukemia (K-562), ova-rian cancer (OVACAR-3), human colon adenocarcinoma (HT-29) and Human kidney carcinoma (A-498). The in vivo activity was performed in female Swiss albino mice against Ehrlich Ascites Carcinoma (EAC). Among the synthesized compounds, o-iodoanilide, m-iodoanilide and p-iodoanilide derivatives of 2-(4-methyl benzene sulphonyl)-pentanedioic acid amides showed encouraging activity in both the in vitro and in vivo compared to other compounds.

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Author Biography

Satyajit Dutta, Department of Pharmaceutical Chemistry, IIMT College of Medical Sciences, Meerut 250001, Uttar Pradesh
Assistant Professor

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Published
2014-08-01
How to Cite
Dutta, S., D. Kumar, A. Mishra, S. Ray, and K. Nagarajan. “Design, Docking, Synthesis and Anticancer Activity of Some Novel 2-(4-Methylbenzenesulphonamido)pentanedioic Acid Amide Derivatives”. Bangladesh Journal of Pharmacology, Vol. 9, no. 3, Aug. 2014, pp. 328-36, doi:10.3329/bjp.v9i3.19132.
Section
Research Articles