Cardiovascular inhibitory properties of Lens culinaris

  • Munasib Khan Natural Products Research Unit, Department of Biological and Biomedical, Sciences, Aga Khan University Medical College, Karachi-74800, Pakistan Department of Pharmacy, University of Malakand, Chakdara, Dir (L), Pakistan
  • Arif-ullah Khan Department of Pharmacology, Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad
  • Najeeb-ur Rehman Department of Pharmacy, College of Health Sciences, Mekelle University, Mekelle
  • Anwarul-Hassan Gilani Natural Products Research Unit, Department of Biological and Biomedical, Sciences, Aga Khan University Medical College, Karachi
Keywords: Lens culinaris, hypotensive, vasodilator, cardio-depressant

Abstract

In present study, we report the blood pressure lowering, vasodilatory and cardio-depressant activities of Lens culinaris. The crude extract of L. culinaris induced dose-dependent (3-30 mg/kg) fall in the arterial pressure of rats under anesthesia. When tested in rat aortic ring preparations, L. culinaris at concentration range of 0.03-5.0 mg/mL relaxed high K+ (80 mM) and phenylephrine (1 ?M)-induced contractions, like that caused by verapamil. In isolated guinea-pig atria, L. culinaris caused inhibition of atrial force and rate of spontaneous contractions, similar to that exhibited by verapamil. These data indicate that L. culinaris exhibits blood pressure lowering potential, mediated possibly through Ca++ channel blockade mechanism.

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References

Ajay M, Chai HJ, Mustafa AM, Gilani AH, Mustafa MR. Mechanisms of the antihypertensive effect of Hibiscus sabdariffa L. calyces. J Ethnopharmacol. 2007; 109: 388-93.

Consolini AE, Baldini OAN, Amat AG. Pharmacological basis for the empirical use of Eugenia uniflora L. (Myrtaceae) as antihypertensive. J Ethnopharmacol. 1999; 66: 33-39.

Farre AJ, Columbo M, Fort M, Gutierrez B. Differential effects of various Ca++ antagonists. Gen Pharmacol. 1991; 22: 177-81.

Fleckenstein A. Specific pharmacology of Ca++ in myocardium, cardiac pacemakers and vascular smooth muscle. Rev Pharmacol Toxicol. 1977; 17: 149-66.

Ghayur MN, Gilani AH. Ginger lowers blood pressure through blockade of voltage-dependent calcium channels. J Cardiovasc Pharmacol. 2005; 45: 74-80.

Ghayur MN, Janssen LJ. A natural way to cardiovascular health. Nat Rev Cardiol. 2010; 7: 1-2.

Gilani AH, Atta-ur-Rahman. Trends in ethnopharmacology. J Ethnopharmacol. 2005; 100: 43-49.

Gilani AH, Ghayur MN, Houghton PJ, Jabeen Q, Kazim SF, Jumani MI, Saeed SA. Studies on the hypotensive, cardio-suppressant, vasodilator and antiplatelet activities of betel nut crude extract and its constituents. Int J Pharmacol. 2006; 2: 33-41.

Gilani AH, Khan AU, Shah AJ, Cornor JD, Jabeen Q. Blood pressure lowering effect of olive is mediated through calcium channel blockade. Int J Food Sci Nutrit. 2005; 56: 613-20 .

Godfraind T, Miller R, Wibo M. Calcium antagonism and calcium entry blockade. Pharmacol Rev. 1986; 38: 321-416.

Johansen PL. Hemodynamic effects of calcium antagonists in hypertension. In: Calcium antagonists in clinical medicine. Epstein M, (ed). Philadelphia USA. Hanley and Belfus. 1992, pp 62-98.

Joseph JS, Barry LC, Hypertension In: DiPiro, JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey LM, (eds). The pharmacotherapy: A pathophysiologic approach. 6th ed. New York, McGraw-Hill, 1999, p 208.

Khan A, Gilani AH. Pharmacodynamic evaluation of Terminaliabellerica for its antihypertensive effect. J Food Drug Anal. 2008; 16: 6-14.

Khan AU, Gilani AH . Blood pressure lowering, cardiovascular inhibitory and bronchodilatory activities of Achillea millefolium. Phytother Res. 2011; 25: 577-83.

Khan M, Khan AU, Najeeb-ur-Rehman, Gilani AH. Pharmacological basis for the medicinal use of Lens culinaris in gastrointestinal and respiratory disorders. Phytother Res. 2014; doi: 10.1002/ptr.5136: [Epub ahead of print] .

Khan M, Khan AU, Najeeb-ur-Rehman, Zafar MA, Hazrat A, Gilani AH. Cardiovascular effects of Juniperus excelsa are mediated through multiple pathways clinical and experimental hypertension. Clin Exp Hypertens. 2012; 34: 209-16.

Khan M, Shah AJ, Gilani AH. Antidiarrheal and antispasmodic activities of Vitex negundo are mediated through calcium channel blockade. Bangladesh J Pharmacol. 2013; 8: 317-22.

Musha S, Watanabe M, Ishida Y, Kato S, Konishi M, Tomoda A. A phenoxazine compound, 2-amino-4,4α-dihydro-4α-7-dimethyl-3H-phenoxazine-3-one reverses the phenylephrine or high-K+ induced contractions of smooth muscles in rat aorta and guinea-pig tenia cecum. Biol Pharm Bull. 2005; 28: 1521-23.

Okmura K, Ichihara K, Nagaska M, Oda N, Tajima K. Calcium entry blocking activities of MPC-1304 and of its enantiomers and metabolites. Eur J Pharmacol. 1993; 235: 69-74.

Wang GJ, Shum AY, Lin YL, Liao JF, Wu XC, Ren J, Chen CF. Calcium channel blockade in vascular smooth muscle cells: Major hypotensive mechanism of S-petasin, a hypotensive sesquiterpene from Petasites formosanus. J Pharmacol Exp Ther. 2001; 297: 240-46.

Published
2014-07-22
How to Cite
Khan, M., A.- ullah Khan, N.- ur Rehman, and A.-H. Gilani. “Cardiovascular Inhibitory Properties of Lens Culinaris”. Bangladesh Journal of Pharmacology, Vol. 9, no. 3, July 2014, pp. 303-6, doi:10.3329/bjp.v9i3.19090.
Section
Research Articles