Hepatoprotective effect of leaves of aqueous ethanol extract of Cestrum nocturnum against paracetamol-induced hepatotoxicity

  • M. Imran Qadir College of Pharmacy, GC University, Faisalabad
  • Muhammad Sajid Al Murad College of Pharmacy, GC University, Faisalabad
  • Muhammad Ali Institute of Molecular Biology & Biotechnology, Bahauddin Zakariya University, Multan
  • Mohammad Saleem College of Pharmacy, GC University, Faisalabad
  • Ammad Ahmad Farooqi Laboratory for Translational Oncology and Personalized Medicine, RLMC, 35 Km Ferozepur Road, Lahore
Keywords: Cestrum nocturnum, Hepatoprotective, Paracetamol, Silymarin

Abstract

The hepatoprotective activities of Cestrum nocturnum (Queen of Night) was evaluated against the paracetamol induced hepatotoxicity in the mice. Aqueous ethanol (30:70) extract of plant was obtained by maceration. Results showed that aqueous ethanol extract of C. nocturnum (250 mg/kg and 500 mg/kg) produced significant (p<0.05) hepatoprotective activities against paracetamol induced liver injury in Swiss albino mice. Histopathalogical studied of liver further supported the hepatoprotective effects of C. notrunum. Phytochemical screening showed the presence of alkaloids, flavonoids, saponins, terpenes, phenolic compounds, carbohydrates and volatile oils. Most of the flavonoids have hepatoprotective activity. Therefore, the hepatoprotective activity of C. nocturnum may be due to the presence of flavonoids and phenolic components. It was concluded from the present study that aqueous ethanol extract of leaves of C. nocturnum has hepatoprotective activity against the paracetamol-induced hepatotoxicity in albino mice.

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Author Biography

M. Imran Qadir, College of Pharmacy, GC University, Faisalabad
Assistant Professor

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Published
2014-04-01
How to Cite
Qadir, M. I., M. S. A. Murad, M. Ali, M. Saleem, and A. A. Farooqi. “Hepatoprotective Effect of Leaves of Aqueous Ethanol Extract of Cestrum Nocturnum Against Paracetamol-Induced Hepatotoxicity”. Bangladesh Journal of Pharmacology, Vol. 9, no. 2, Apr. 2014, pp. 167-70, doi:10.3329/bjp.v9i2.17770.
Section
Research Articles