Attenuation of hyperglycemia and hyperlipidemia in high calorie fed/streptozotocin-treated rats by hydromethanolic extract of Padina tetrastromatica

  • Divya S. Mohan Department of Biochemistry, University of Kerala, Kariavattom Campus, Thiruvananthapuram 695 581, Kerala
  • Mini Saraswathy Department of Biochemistry, University of Kerala, Kariavattom Campus, Thiruvananthapuram 695 581, Kerala
  • Muraleedhara Kurup Gopala Kurup Department of Biochemistry, University of Kerala, Kariavattom Campus, Thiruvananthapuram 695 581, Kerala
Keywords: Antihyperglycemic, Antihyperlipidemic, Diabetes mellitus, Padina tetrastromatica

Abstract

In the present study, the effect of defatted hydromethanolic extract of Padina tetrastromatica on carbohydrate metabolism and serum lipid profile were evaluated. Diabetes mellitus was induced in male Wistar rats by feeding high calorie/energy diet for two months followed by a single intraperitoneal injecttion of streptozotocin. Diabetic rats were administered with the extract intragastrically at doses of 150, 300, 450, and 600 mg/kg body weight daily for 45 days. Treatment with graded doses showed a dose dependent reduction in blood glucose and glycated hemoglobin levels. Treatment significantly increased the activity of hexokinase, glucose-6-phosphate dehydrogenase and glycogen content while there was significant reduction in the activity of glucose-6-phosphatase and fructose-1,6-bisphosphatase. Serum lipid profile was also brought back to near normal levels in a dose dependent manner. The present study clearly indicates the antihyperglycemic and hypolipidemic effects of P. tetrastromatica at an optimum dose of 450 mg/kg body weight.

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Published
2014-01-25
How to Cite
Mohan, D., M. Saraswathy, and M. Kurup. “Attenuation of Hyperglycemia and Hyperlipidemia in High Calorie Fed/Streptozotocin-Treated Rats by Hydromethanolic Extract of Padina Tetrastromatica”. Bangladesh Journal of Pharmacology, Vol. 9, no. 1, Jan. 2014, pp. 37-42, doi:10.3329/bjp.v9i1.17153.
Section
Research Articles