Antimicrobial, antioxidant and calcium channel blocking activities of Amberboa divaricata

  • Shahid Muhammad Iqbal Department of Pharmacy, Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur, Bahawalpur
  • Aamir Mushtaq Department of Pharmacy, Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur, Bahawalpur
  • Qaiser Jabeen Department of Pharmacy, Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur, Bahawalpur
Keywords: Amberboa divaricata, Antibacterial, Antioxidant, Ca Channels, Spasmolytic

Abstract

Traditional healers in Pakistan use the herb Amberboa divaricata as tonic, aperiant, deobstruent, febrifuge, antidiarrheal, antiperiodic, antipyretic, anti-cough and in skin disorders. In vitro tissue experiments were carried out on rabbit jejunum to elucidate the possible mechanism of its prescribed effects on gastrointestinal tract, while antibacterial and antioxidant experiments were performed to provide pharmacological evidence of its traditional use in skin disorders. The 70%methanolic crude extract of A. divaricata produced dose dependent relaxation in isolated rabbit jejunum tissue in a concentration range of 0.13.0 mg/mL (n=5). Calcium response curves were constructed at concentration of 0.03 and 0.1 mg/mL (n=5), which produced rightward shift in a pattern similar to that of verapamil, confirming the calcium channel blocking activity. Agar disc diffusion assay at a concentration of 10 mg crude extract/disc showed clear zones of inhibition.

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Published
2014-01-20
How to Cite
Iqbal, S., A. Mushtaq, and Q. Jabeen. “Antimicrobial, Antioxidant and Calcium Channel Blocking Activities of Amberboa Divaricata”. Bangladesh Journal of Pharmacology, Vol. 9, no. 1, Jan. 2014, pp. 29-36, doi:10.3329/bjp.v9i1.16989.
Section
Research Articles