Hypoglycemic activity and the activation of phosphorylation of a triterpenoid-rich extract from Euryale shell on streptozotocin-induced diabetic mice

  • Huaibo Yuan College of Biotechnology and Food Engineering, Hefei University of Technology, Hefei
  • Shaohua Meng College of Biotechnology and Food Engineering, Hefei University of Technology, Hefei
  • Zhaobin Gong College of Biotechnology and Food Engineering, Hefei University of Technology, Hefei
  • Deyi Chen College of Biotechnology and Food Engineering, Hefei University of Technology, Hefei
  • Cuan Zhang School of Bio and Food Engineering, Chuzhou University, Chuzhou
Keywords: Euryale shell, Hypoglycemic, Triterpenoid rich extract

Abstract

In the present study, we examined the hypoglycemic properties and the effective mechanisms of a triterpenoid-rich extract from the Euryale shell (ES) in streptozotocin-induced (STZ) diabetic mice. The hydroalcoholic extract of ES (200, 400 and 600 mg/kg/day) was orally administered to STZ-diabetic mice for 4 weeks. We observed that in the liver of diabetic mice, the ES extract caused a sharp reduction in the gene expression of protein tyrosine phosphatase-1B (PTP1B) but induced the gene expression of phosphatidyl-inositol-3-kinase (PI-3K) and protein kinase B (PKB) compared with that of untreated diabetic mice. Additionally, a significant increase in the phosphorylation of the PKB protein was observed (p<0.01). This was corroborated by the inhibition of PTP1B and by the regulation of glucose uptake via PI-3K activation, which together demonstrate that the reduction of PTP1B can modulate key insulin signaling events downstream of the insulin receptor. 

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Published
2013-05-13
How to Cite
Yuan, H., S. Meng, Z. Gong, D. Chen, and C. Zhang. “Hypoglycemic Activity and the Activation of Phosphorylation of a Triterpenoid-Rich Extract from Euryale Shell on Streptozotocin-Induced Diabetic Mice”. Bangladesh Journal of Pharmacology, Vol. 8, no. 3, May 2013, pp. 230-5, doi:10.3329/bjp.v8i3.14718.
Section
Research Articles