Phytochemical screening and antipyretic effects of hydro-methanol extract of Melia azedarach leaves in rabbits


  • Sabira Sultana University College of Conventional Medicine, Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur
  • Naveed Akhtar University College of Conventional Medicine, Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur
  • Hafiz Muhammad Asif Department of Eastern Medicine and Surgery, Faculty of Health & Medical Sciences, The University of Poonch, Rawalakot, AJ & K



Melia azedarach, hydro-methanol extract, antipyretic activity


The antipyretic effect of the hydro-methanol extract of Melia azedarach leaves was investigated using the yeast induced pyrexia method in rabbits. Paracetamol was used as a positive control and negative control group received distilled water. Rectal temperatures of all rabbits were recorded immediately before the administration of the extract or vehical or paracetamol and again at 1 h interval for 6 h using digital thermometer. The extract was also phytochemically screened for alkaloids, tannins, saponins, flavonoids, cardiac glycosides and phenols. At 500 mg/kg dose the extract showed significant (p<0.0001) reduction in yeast-induced elevated temperature as compared with that of standard drug paracetamol whereas the extract dose 250 mg/kg was less effective when compared with higher dose (p<0.05). Phytochemical screening showed the presence of alkaloids, tannins, flavonoids, saponins and phenols. This study showed that the hydro-methanol extract of M. azedarach leaves at a dose of 500 mg/kg possesses significant antipyretic effect against the yeast-induced elevated temperature.


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How to Cite

Sultana, S., N. Akhtar, and H. M. Asif. “Phytochemical Screening and Antipyretic Effects of Hydro-Methanol Extract of Melia Azedarach Leaves in Rabbits”. Bangladesh Journal of Pharmacology, vol. 8, no. 2, May 2013, pp. 214-7, doi:10.3329/bjp.v8i2.14708.



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